BRAIN ERPS AND COGNITIVE DEMAND IN SCHIZOPHRENIA

精神分裂症患者的P300波幅降低 脑事件相关电位(ERP)到音调，已有报道称 在一些研究中，最大值出现在左侧颞区。我们的预赛 研究重复了这一发现，并发现了左脑减少的证据 二分词的优势，这在精神分裂症患者中最为显著 有阳性症状的患者。该项目旨在确定其效果 认知任务需求对P300降低和不对称性的影响 精神分裂症，并探讨P3OO异常与分裂的关系 对症状特征的听力不对称(即，思维障碍和 幻听)、性别和家族性传播 精神分裂症。一个更长远的目标是确定潜在的价值 脑部事件相关电位作为常规药物治疗反应的预测指标 抗精神病药或氯氮平。 ERP任务需求将使用动词(无意义音节)和 简单双耳“古怪”任务中的非语言(复杂音调)刺激 难度更大的双耳听力任务。事件相关电位与行为反应 将被记录在90名精神分裂症患者和30名正常对照中。 患者将在至少四周的无药期后接受测试 氟哌啶醇治疗6周后。治疗无效者 接受氯氮平治疗6周后将再次接受测试。 此外，至少30名精神分裂症患者的事件相关电位 未服药期间和所有正常对照将在 连续单词识别任务，这被认为是反映左内侧的 颞叶功能。临床评级将在以下几个方面获得 量表包括：积极与消极症状量表、思维障碍 索引和BPRS。听觉知觉中的事件相关电位和行为测量 记忆任务应该为评估提供一致的证据 存在左颞叶功能障碍的假说 症状阳性、反应明显的精神分裂症亚型 到抗精神病药。

Schizophrenic patients have shown a reduction in the amplitude of the P30O brain event-related potential (ERP) to tones, which has been reported to be maximal over the left temporal region in some studies. Our preliminary study replicated this finding and found evidence of reduced left brain dominance for dichotic words, which was most marked in schizophrenic patients with positive symptoms. This project aims to determine the effect of cognitive task demands on P300 reduction and asymmetry in schizophrenia, and to examine the relation of abnormal P3OO and dichotic listening asymmetry to symptom features (i.e., thought disorder and auditory hallucinations), gender and familial transmission of schizophrenia. A more long range goal is to determine the potential value of brain ERPs as predictors of therapeutic response to a conventional neuroleptic or to clozapine. ERP task demands will be manipulated using verbal (nonsense syllable) and nonverbal (complex tone) stimuli in easy binaural "oddball" tasks and in more difficult dichotic listening tasks. ERPs and behavioral responses will be recorded in 90 schizophrenic patients and 30 normal controls. Patients will be tested after a minimum 4 week drug-free period and again after 6 weeks of treatment with haloperidol. Treatment nonresponders who receive clozapine will be retested again after 6 weeks on this medication. In addition, ERPs of at least 30 of the schizophrenic patients in the unmedicated period and all normal controls will be measured during a continuous word recognition task, which is thought to reflect left medial temporal lobe function. Clinical ratings will be obtained on several scales including: Positive and Negative Syndrome Scale, Thought Disorder Index, and BPRS. ERP and behavioral measures in the auditory perception and memory tasks should yield converging evidence for evaluating hypotheses concerning the existence of left temporal lobe deficits in a subtype of schizophrenia with positive symptoms and distinctive response to neuroleptics.