Physical Activity, Ovarian and Endometrial Cancer Risk

描述(由申请人提供)： 体育锻炼对健康有很多好处，包括降低患结肠癌和乳腺癌的风险。体力活动也可能改变患子宫内膜癌和上皮性卵巢癌的风险。很少有研究研究这些潜在的关系。以前的大多数研究都是病例对照研究或使用替代活动测量的记录关联研究。我们建议利用收集的数据作为加州教师研究(CTS)的一部分，CTS是一项对133,479名女教师和学校管理人员进行的队列研究，于1995年启动，以解决是否 1.平均每周从事4小时或以上中等强度体力活动的女性患子宫内膜癌和卵巢癌的风险较低； 2.剧烈的体力活动比适度的体力活动能更好地预防子宫内膜癌和卵巢癌。 此外，我们建议分析从一组基于人群的对照受试者收集的数据，以比较他们对自我填写的邮寄的CTS体力活动问卷的反应与他们对收集的终身体力活动历史的深入面谈的反应，以确定这两种类型的问卷测量的体力活动方面是否相同或不同，并确定人口统计或其他因素是否影响从两种问卷方法获得的信息的可比性。

DESCRIPTION (provided by applicant): Physical activity has numerous health benefits including a reduction in risk of colon and breast cancer. Physical activity may also alter the risk of endometrial cancer and epithelial ovarian cancer. Few studies have examined these potential relationships. Most prior studies have been case-control studies or record linkage studies that have used surrogate measures of activity. We propose to utilize data collected as part of the California Teachers Study (CTS), a cohort study of 133,479 female teachers and school administrators that was initiated in 1995, to address whether 1. Women who engage in moderate and strenuous physical activity for 4 or more hours per week on average, have a reduced risk of endometrial cancer and of ovarian cancer; 2. Strenuous physical activity provides greater protection against endometrial cancer and ovarian cancer than does moderate physical activity. Additionally we propose to analyze data collected from a group of population-based control subjects to compare their responses to the self-completed, mailed CTS questionnaire on physical activity to their responses to an in-depth, in-person interview that collected lifetime history of physical activity to determine whether the two types of questionnaires measure the same or different aspects of physical activity and to determine whether demographic or other factors affect the comparability of information derived from the two questionnaire approaches.