Conference--Smooth Muscle

描述(由申请人提供)： 要求为将于7月5日至10日在科罗拉多州斯诺马斯举行的2003年FASEB平滑肌肉会议提供部分资金。这次会议是自1982年以来每三年举行一次的一系列非常成功的平滑肌会议中的第八次。FASE B平滑肌肉会议被广泛认为是平滑肌肉生物学领域的首要论坛。这些会议非常受欢迎，来自澳大利亚、亚洲、欧洲和北美的主要调查人员参加了会议。对于那些对心血管、呼吸、生殖、消化和尿路生理学和病理生理学感兴趣的人来说，对平滑肌功能的了解是至关重要的。因此，这次会议定期吸引来自几个学科的基础科学和临床研究人员。在过去的3年里，利用分子生物学、细胞和亚细胞共聚焦成像、膜片钳等技术取得了快速的进展，对肌丝相互作用、平滑肌的发育和可塑性、离子通道的识别和调节、第二信使系统、Ca~(2+)信号和细胞与细胞之间的相互作用有了新的认识。由于许多平滑肌研究人员致力于特定的器官系统(即心血管系统)的研究，并经常参加与这些器官系统的细节相关的社会会议，因此召开一次讨论与平滑肌肉的细胞和组织生物学相关的共同问题的全面的平滑肌会议是极其重要的。20多年来，FASE B平滑肌肉会议一直在满足这一迫切需求。会议的形式特别有利于非正式讨论和形成新合作的机会。除了申请书中描述的编排好的讲座并组织成9个专题研讨会外，年轻研究人员的来稿将从提交的摘要中挑选出来，并作为口头陈述添加到研讨会中。2003年FASE B平滑肌肉会议将全面回顾平滑肌肉生物学的最新进展，并为开始在该领域进行研究的科学家或对平滑肌肉功能有更广泛临床兴趣的临床研究人员提供一个密集的短期课程。非正式互动的广泛机会将使各级调查人员能够结识新同事，探索新的想法和技术，并发展新的合作。

DESCRIPTION (provided by applicant): Partial support is requested for the funding of the 2003 FASEB Smooth Muscle Conference to be held from July 05-10th at Snowmass, Colorado. This conference is the 8th in a highly successful series of smooth muscle meetings that have been held every 3 years since 1982. The FASEB Smooth Muscle Conferences are widely regarded as the premier forum in the field of smooth muscle biology. The meetings have been extremely popular and attended by leading investigators from Australia, Asia, Europe and North America. An understanding of smooth muscle function is vital to those interested in cardiovascular, respiratory, reproductive, digestive and urinary tract physiology and pathophysiology. Thus, this conference regularly attracts both basic science and clinical investigators from several disciplines. Rapid progress has been made during the past 3 years using techniques such as molecular biology, cellular and sub-cellular confocal imaging, and patch clamping, and new insights have been gained about myofilament interactions, development and plasticity of smooth muscles, ion channel identity and regulation, second messenger systems, Ca2+ signaling, and cell-to-cell interactions. Because many smooth muscle investigators work on specific organ systems (i.e. cardiovascular system) and frequently attend society meetings related to the specifics of these organ systems, a comprehensive smooth muscle meeting where common issues related to the cell and tissue biology of smooth muscles are discussed is extremely important. The FASEB Smooth Muscle Conferences have served this critical need for over 2 decades. The format of the meeting is especially conducive to informal discussion and opportunities to form new collaborations. In addition to the programmed lectures described in the application and organized into 9 topical symposia, contributions from young investigators will be selected from the abstracts submitted and added to the symposia as oral presentations. The 2003 FASEB Smooth Muscle Conference will provide a comprehensive review of recent progress in smooth muscle biology and constitute an intensive short course for scientists who are beginning investigations in the field or clinical investigators with broader clinical interests in smooth muscle function. The extensive opportunities for informal interactions will allow investigators at all levels to meet new colleagues, explore new ideas and techniques, and develop new collaborations.