RISK MARKERS FOR DEMENTIA AFTER STROKE

描述(改编自申请者摘要)：痴呆症和认知 与中风相关的损害是一种重要但神秘的公共卫生 有问题。由于许多中风患者都是老年患者，因此伴随着病理生理 机制可能在他们痴呆症的发生中发挥作用。现在，小说 定量核磁共振成像技术是一种潜在的强大的 活体研究工具，可能确定导致痴呆的因素和 卒中患者的认知功能障碍。这项建议的主要目的是 为了确定诸如海马区和内嗅区皮质体积等风险标志物， 脑白质功能障碍、每搏出量和一般脑体积 可能导致痴呆症和认知障碍的定量核磁共振技术 中风患者的功能障碍。申请者提议使用一种新技术 磁共振定量分析，弥散张量扫描，研究病变 大脑的白质。拟议的分析将考虑核磁共振和 其他可能在中风后痴呆的发生中起重要作用的因素 有或无缺血性卒中患者的病例对照研究 患上痴呆症。申请者建议研究核磁共振的贡献 中风患者阿尔茨海默病(AD)的标志物。在那些划水中 没有显示AD定量MRI标志物的患者，可能会 开始给“血管性痴呆”下定义。调查结果将通过以下方式进行验证 来验尸的患者之间的神经病理相关性。通过定义 定量MRI分析在卒中后痴呆患者中的作用 申请者提议澄清“血管性痴呆”的概念。他们说 我们对痴呆症的机制和原因的了解的改进 中风患者可能会导致预防和治疗的改善 战略。

DESCRIPTION (Adapted from Applicant's Abstract): Dementia and cognitive impairment associated with stroke are an important but enigmatic public health problem. As many stroke patients are elderly, concomitant pathophysiologic mechanisms may play a role in the genesis of their dementia. Now, novel quantitative MRI imaging technology is available as a potentially powerful in vivo research tool that may identify factors that contribute to dementia and cognitive impairment in patients with stroke. The major aim of this proposal is to identify risk markers such as hippocampal and entorhinal cortex volume, white matter dysfunction, stroke volume, and generalized brain volume by quantitative MRI technology that may contribute to dementia and cognitive impairment in stroke patients. The applicants propose to use a new technology of quantitative MRI analysis, diffusion tensor scanning, to study diseased white matter of the brain. The proposed analysis will take into account MRI and other factors that may be important in the genesis of dementia after stroke by case-control methodology among ischemic stroke patients who do or do not develop dementia. The applicants propose to study the contribution of MRI markers of Alzheimer's disease (AD) in stroke patients. In those stroke patients who do not show quantitative MRI markers for AD, it may be possible to begin to define 'vascular dementia.' The findings will be validated by neuropathologic correlation among patients who come to autopsy. By defining the role of quantitative MRI analysis in dementia patients after stroke, the applicants propose to clarify the concept of 'vascular dementia.' They state that refinement in our knowledge of mechanisms and causes for dementia in stroke patients may lead to an improvement in prevention and treatment strategies.