COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL

描述(改编自申请者摘要)：密钥强化计划 对目前TRS乳腺癌显像仪的改进将增加 探测器、动态范围和测量的参数数量 提高精度、分辨率、覆盖范围、动态范围和功能 基于吸收和荧光研究的检测能力 本征和外源性造影剂。将对这些改进进行评估 通过计算机模拟和轶事人类主题研究逐一进行。 增强的成像性能将使用微扰漫射进行研究 光学层析成像(DOT)，并将用单光学和多光学进行测试 作为源探测器对，投影角， 频率和信噪比。这些改进也将得到测试 利用人类乳腺肿瘤的轶事斑点图像利用这些仪器 和理论上的改进，其中增强了与Gd的共同配准 MRI、氟脱氧葡萄糖、PET和组织病理学提供了金标准。轶事 然后对临床数据进行处理，以进行a)图像重建，以及b) 磁共振成像中指定体素的拟合程序。主要图像和贴合效果将 基于Gd增强MRI或和 分别进行组织病理学检查。其他特征，尤指肿瘤的氧合 根据血红蛋白饱和度估计的结果将被比较，用于成像 重建，使用PET，为了提高肿瘤诊断能力，使用 组织病理学。将对光散射进行类似的两层分析 在正常和荷尔蒙激活的乳房中。通过这种方式，DOT的能力 对于图像重建和特征提取，将进行适当的评估 确保这些乳腺癌新方法有效的研究 侦测。可在其他支持下进行大规模测试，如果直接 不仅与MRI，而且与数字乳房摄影、超声和PET的比较 将确保验证研究的安全。

DESCRIPTION (Adapted from Applicant's Abstract): An intensive program of key improvement of the current TRS breast cancer imager will increase the number of detectors, the dynamic range, and the number of parameters measured leading to increased accuracy, resolution, area of coverage, dynamic range and feature detection ability based upon both absorption and fluorescence studies of intrinsic and extrinsic contrast agents. These improvements will be evaluated one by one by computer simulation and anecdotal human subject studies. Increased imaging performance will be studied using perturbative diffusive optical tomography (DOT) and will be tested with single and multiple optical heterogeneities as a function of source detector pairs, projection angles, frequencies and signal to noise ratios. These improvements will also be tested with anecdotal DOT images of human breast tumor exploiting these instrumental and theoretical improvements in which coregistration with gadolinium enhanced MRI fluorodeoxy glucose PET and histopathology afford gold standards. Anecdotal clinical data will then be processed for a) image reconstruction, and b) fitting procedures in MRI designated voxels. The primary images and fits will be based upon evaluation with gadolinium enhanced MRI or and with histopathology respectively. Other features, especially tumor oxygenation as estimated from hemoglobin saturation will be compared, for imaging reconstruction, with PET and, for tumor diagnostic capability, with histopathology. A similar two tiered analysis will be made of light scattering in normal and hormonally activated breast. In this way the capability of DOT for image reconstruction and feature extraction will be evaluated with adequate studies to ensure validation of these novel approaches to breast cancer detection. Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies.