Study of Peripheral Immune Effects and Pathway on Brain

描述(申请人提供)：有越来越多的实验和临床证据支持中枢神经系统和免疫系统之间的密切沟通以维持体内平衡和健康的概念。数据支持这样一个事实，即这种相互关系是双向的，即免疫系统受到神经内分泌因素的调节，反之亦然。先进传感器技术公司(AST)建议将其现有的一些专有技术结合起来，创建一种装有传感器的模块化灌流生物反应器，以进行体外研究，以更好地了解和阐明这些细胞通信手段。由于AST的模块化灌流生物反应器能够在体外密切模拟体内条件，因此可以阐明神经、内分泌和免疫系统之间的密切联系。这一拟议研发项目的成果将提供：(A)一个商业上可行的生物反应器平台，首先由研究界(大学)使用，然后由开发界(药物发现公司)使用；(B)对细胞通信的轴心有基本的科学见解。AST的传感器装配的模块化灌流生物反应器能够监测各种生物分子的浓度，包括神经激素，如精氨酸加压素、促肾上腺皮质激素释放因子、促性腺激素释放激素和β-内啡肽。

DESCRIPTION (provided by applicant): There exists a growing body of evidence, both experimental and clinical, which supports the concept of intimate communication between the central nervous and immune systems to maintain homeostasis and health. Data support the fact that this interrelationship is bi-directional, such that the immune system is subject to regulation by neuroendocrine factors and vice versa. Advanced Sensor Technologies, Inc (AST) proposes to combine a number of its existing proprietary technologies to create a sensor-fitted, modular, perifusion bioreactor to perform in vitro studies to better understand and elucidate these means of cellular communication. Since AST's modular perifusion bioreactor is capable of closely mimicking in vivo conditions in vitro, the intimate communication between the nervous, endocrine, and immune systems can be elucidated. The results of this proposed research and development project will provide: (a) a commercially viable bioreactor platform that will be utilized first by the research communities (universities) followed by the development communities (drug discovery companies); (b) basic scientific insight into the axes of cellular communication. AST's sensor-fitted, modular, perifusion bioreactor is capable of monitoring the concentrations of a wide variety of biological molecules, including neurohormones such as arginine vasopressin, corticotropin releasing factor, gonadotropin releasing hormone, and beta-endorphin.