Enhanced Nitric Oxide-Releasing Materials

描述(申请人提供)：这项研究的目标是将释放一氧化氮(NO)的化合物加入聚合物配方中，可用于改善血管内和体外设备中血液接触表面的生物相容性。以前的研究已经证明，在表面涂覆一层持续释放少量NO的聚合物层，可以抑制血小板的激活和黏附。早期材料的实际应用受到限制，因为它们不够稳定，不能承受制造和储存，而且因为低容量不需要非常厚的涂层。没有开发出新的捐助者来解决这些问题。这种材料具有显著更高的NO容量；因此，更薄的涂层可以提供更多的NO。这些材料的保质期也比它们的前身更长。两个NO供体将被用来形成聚合物涂层，这种涂层可以应用于套管、导管和体外血液处理设备中常用的材料。将设计配方，以尽可能少的涂层材料提供足够的无剂量。这些材料将接受测试，以确定它们在制造、灭菌和储存过程中的典型条件下的承受能力。动物模型将被用来评估生物相容性和材料防止血小板激活和粘连的能力。

DESCRIPTION (provided by applicant): The goal of this study is to incorporate nitric oxide (NO)-releasing compounds into polymer formulations that can be used to improve the biocompatibility of blood-contact surfaces in intravascular and extracorporeal devices. Previous studies have demonstrated that coating surfaces with polymer layers that continuously released small amounts of NO inhibited platelet activation and adhesion. Earlier materials had limited practical applications because they were not sufficiently stable to withstand manufacturing and storage, and because low NO capacity required prohibitively thick coatings. New NO donors have been developed that address these issues. The materials have significantly higher NO capacities; so more NO can be delivered with thinner coatings. These materials also have longer shelf life than their predecessors. Two NO donors will be used to form polymer coatings that can be applied to materials commonly used in cannulas, catheters, and extracorporeal blood treatment devices. Formulations will be devised to provide sufficient NO dose with the minimum possible coating material. The materials will be tested for their ability to withstand conditions typical in manufacturing, sterilization and storage. An animal model will be employed to evaluate biocompatibility and the ability of the materials to prevent platelet activation and adhesion.