Limited Access Dataset: The ACTIVE Study

描述（由申请人提供）：本R 03的具体目的是为1998-2001年进行的独立和重要老年人高级认知训练（ACTIVE）试验创建有限访问数据集。ACTIVE是一项由NIA和NINR申办的随机、对照、单盲临床试验。本试验在6个现场中心（伯明翰大学;希伯来老年人康复中心，波士顿;印第安纳州大学;约翰霍普金斯大学;宾夕法尼亚州立大学;和韦恩州立大学）进行。ACTIVE的主要目的是测试三种不同的认知干预措施在改善老年人基本认知指标和认知要求日常活动指标方面的有效性和持久性（例如，食物准备、驾驶、药物使用、财务管理）。该试验采用了四组设计，包括三个治疗组（记忆训练，推理训练或处理速度训练）和一个无接触对照组。共有2，832人参加了试验。由于其规模和精心开发的严谨性，其数据集为研究人员提供了大量的二次分析机会。将对ACTIVE数据集进行修改，以确保所有ACTIVE参与者和机构的隐私保护。重新格式化的数据集将以只读格式存档在光盘上，并附有所有相关的测量工具、变量说明和汇总表以及综合文件。ACTIVE试验的协调中心（新英格兰研究所）将执行这项工作。

DESCRIPTION (provided by applicant): The Specific Aim of this R03 is to create Limited Access Datasets for the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial, which was conducted from 1998-2001. ACTIVE was a randomized, controlled, single-blind clinical trial sponsored by the NIA and the NINR. The trial was conducted at 6 field sites (University of Alabama-Birmingham; Hebrew Rehabilitation Center for the Aged, Boston; Indiana University; Johns Hopkins University; Pennsylvania State University; and Wayne State University). The primary objective of ACTIVE was to test the effectiveness and durability of three distinct cognitive interventions in improving elders' performance on basic measures of cognition and on measures of cognitively demanding daily activities (e.g., food preparation, driving, medication use, financial management). The trial employed a four-group design, including three treatment arms (Memory Training, Reasoning Training, or Speed of Processing Training) and a no-contact control group. A total of 2,832 persons were enrolled in the trial. Because of its size and the carefully developed rigor, its datasets offer to investigators a wealth of opportunities for secondary analyses. Modifications will be made to ACTIVE datasets to ensure privacy protection for all ACTIVE participants and institutions. The reformatted datasets will be archived in read-only format on CD-ROM and accompanied by all related measurement instruments, variable descriptions and summary tables, and comprehensive documentation. The Coordinating Center for the ACTIVE trial, the New England Research Institutes, will perform this work.