Health Effects of Occupational Exposures in PGDP Workers

描述(由申请人提供)： Paducah气体扩散厂(PGDP)位于肯塔基州西部，距离Paducah市以西约10英里。它目前雇佣了大约1700名工人；自1952年工厂成立以来，大约有8000人在那里工作。该工厂位于农村地区，毗邻该地点的一些地区是受保护的保护、野生动物和娱乐区。PGDP的主要功能是生产浓缩铀，供商业反应堆使用，或作为进一步浓缩铀的其他工厂的原料。工人、政府官员和周围社区都对核电站目前和过去的暴露可能对健康造成的影响表示担忧。拟议的研究将开发新的信息，以帮助解决这些关切。这些调查将采取双管齐下的方法，评估历史接触对工人死亡率的影响，以及表征最近接触对当前和未来疾病风险的影响。这项可行性研究的具体目标是： 目标1：对Paducah和Oak Ridge的PGDP设施进行实地考察，以启动与这两个重要记录和其他信息来源的直接交流。目标2：开发和完善一组生物标记物，以评估PGDP的暴露和组织对辐射的反应，包括：染色体畸变；体细胞突变；和蛋白质加合物。目标3：开发和验证从PGDP工作人员那里获取、运输和测试生物样本的系统和程序。目标4：确定当前PGDP工作人员暴露水平较高和较低水平。 这项研究的总体目的是评估对可能影响PGDP工作人员健康的历史暴露和可能影响当前和未来疾病风险的最近暴露进行全面调查的可行性。

DESCRIPTION (provided by applicant): The Paducah Gaseous Diffusion Plant (PGDP) is located in Western Kentucky, about 10 miles west of the City of Paducah. It currently employs approximately 1700 workers; some 8,000 individuals have worked at the plant since it was opened in 1952. The plant is in a rural area and some areas adjacent to the site are protected conservation, wildlife and recreation areas. The primary function of the PGDP has been to produce enriched uranium for use by commercial reactors or as feed material for other plants that further enrich the uranium. Workers, government officials and the surrounding community have raised concerns about potential health effects from current and past exposures at the plant. The proposed studies will develop new information to help address these concerns. These investigations will take a two-pronged approach, evaluating the impact of historical exposures on worker mortality, and characterizing the effects of more recent exposures on current and future risk of disease. The specific aims of this feasibility study are: AIM 1: Carry out site visits to the PGDP facility in Paducah and to Oak Ridge, in order to initiate direct communications with these two important sources of records and other information.AIM 2: Develop and refine a panel of biomarkers to assess exposure and tissue response to radiation at PGDP, including: Chromosome Aberrations; Somatic Mutations; and Protein Adducts.AIM 3: Develop and validate systems and procedures to procure, transport and test biological samples from PGDP workers.AIM 4: Identify current PGDP workers with higher and lower levels of exposure. The overall purpose of this study is to assess the feasibility of undertaking a comprehensive investigation of both historical exposures that may have affected the health of PGDP workers and more recent exposures that may affect current and future disease risk.