Pathology Core

核心C：病理学总结/摘要 包括卵巢癌孢子应用程序的个人研究项目需要采购， 卵巢癌和良性卵巢癌患者的组织病理学材料的处理和分析 疾病研究项目需要冷冻和福尔马林固定，石蜡包埋的样本， 肿瘤和正常组织。研究项目还需要患者来源的异种移植模型和类器官， 测试新药的效果并确定耐药性的机制。拟议的病理学核心 增强了已经建立的MD安德森癌症中心妇科肿瘤库和P30- 赞助的MD安德森癌症中心中央组织库，包括支持数据库和内联网 access.核心由经验丰富的妇科病理学家提供组织采集，以确保高- 为参与本SPORE的研究者以及其他SPORE的研究者提供优质组织。 病理学核心的目标是提供冷冻组织、石蜡包埋组织、组织病理学 专业知识、组织阵列、患者来源的异种移植物和与研究特定需求相关的类器官 这些项目都包含了这个SPORE提案。为实现这一目标，提出了以下具体目标 核心目的1是维持卵巢癌的冷冻和石蜡包埋组织库， 卵巢和良性卵巢过程（如囊肿和子宫内膜异位症）。目的2是提供病理学 审查SPORE项目中使用的所有临床标本，并提供组织病理学和 免疫组织化学技术服务。目标3是创建组织微阵列， 异种移植物（PDX）和类器官模型，并维护关系型SPORE数据库。此SPORE数据库 将提供一个虚拟组织库，可与所有SPORE研究者以电子方式共享。

Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The research projects also need patient-derived xenograft models and organoids to test the effects of novel drugs and define the mechanisms of drug resistance. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30- sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high- quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, histopathological expertise, tissue arrays, patient-derived xenografts, and organoids related to the specific needs of the research projects comprising this SPORE proposal. To meet this goal, the following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancers, normal ovaries, and benign ovarian processes (such as cysts and endometriosis). Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological and immunohistochemical technical services as necessary. Aim 3 is to create tissue microarrays, patient-derived xenografts (PDXs), and organoid models and maintain a relational SPORE Database. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.