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中文摘要
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职业提升计划概要/摘要 职业提升计划(CEP)的中心目标是利用MD安德森的资源, 杰出的年轻研究人员,他们将通过使卵巢癌的发病率和死亡率降低, 在这种疾病的早期发现、预防和治疗方面取得了进展。为了实现这一目标, CEP将提供两个奖项,每个奖项每年50,000美元,为期两年,由SPORE资助, 从MD安德森那里拿到了相应的资金每个CEP奖的目的是准备选定的科学家成为 卵巢癌相关学术研究的国际领导者。我们将通过专注于 招募了一批有前途的年轻调查员。我们将与获奖者合作, 制定个性化的发展计划,并为他们提供优秀的临床和实验室导师 和一个指导委员会,正式的课程工作,辅导赠款和论文写作,领导力培训, 参加国家会议,与卵巢癌学者建立联系,完成并出版了一份 转化卵巢癌研究计划。在过去的二十年里,卵巢癌孢子CEP 培养了27名年轻的调查员在最初授予的第一年,三名博士后 学员获得了CEP奖,自2000年以来支持的24名教员中,除两人外,其余都留下来了 13所主要从事卵巢癌研究。17人实现了 联邦同行评审资助和另外五名获奖者获得了竞争性基金会赠款。三 我们2017 - 2021资助周期的获奖者获得了两项卵巢癌研究联盟(OCRA) 奖项,一个CPRIT奖项,一个R01,一个R21和一个U01。自1999年该计划成立以来,我们 CEP获奖者发表了1,100多篇关于卵巢癌的同行评审论文。
英文摘要
Career Enhancement Program SUMMARY/ABSTRACT The central goal of the Career Enhancement Program (CEP) is to use the resources at MD Anderson to train exceptional young investigators who will reduce the morbidity and mortality from ovarian cancer by making advances in the early detection, prevention, and treatment of this disease. To achieve this goal, the SPORE CEP will provide two awards, each of $50,000 annually for up to two years, funded from the SPORE and matching funds from MD Anderson. The intent of each CEP award is to prepare the selected scientists to become international leaders in academic research relevant to ovarian cancer. We will achieve this through focused recruitment of a diverse cadre of promising young investigators. We will work in partnership with awardees to generate individualized development plan and provide them with outstanding clinical and a laboratory mentors and a mentoring committee, formal course work, coaching in grant and paper writing, leadership training, attendance at national meetings, networking with ovarian cancer scholars and completing and publishing a translational ovarian cancer research program. Over the past two decades, the Ovarian Cancer SPORE CEP has developed the careers of 27 young investigators. In the first year of the original grant, three postdoctoral trainees received CEP awards, and of the 24 faculty members supported since 2000, all but two have remained in academic research and 13 are engaged predominantly in ovarian cancer research. Seventeen have achieved federal peer-reviewed funding and five additional awardees have received competitive foundation grants. Three awardees from our 2017-2021 funded cycle have received two Ovarian Cancer Research Alliance (OCRA) Awards, one CPRIT award, one R01, one R21, and one U01. Since the inception of the program in 1999, our CEP awardees have published over 1,100 peer-reviewed papers regarding ovarian cancer.
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Developmental Research Program
The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer
The University of Texas MD Anderson Cancer Center SPORE in Ovarian Cancer
DIRAS3 disrupts K-RAS clustering and signaling, enhancing autophagy and response to autophagy inhibition
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