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中文摘要
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开发研究计划概要/摘要 发展研究计划(DRP)的目的是资助研究人员有前途的项目 他目前的工作可能并不完全集中在卵巢癌上,但他提出了高度创新的建议, 卵巢癌的转化研究,可以成为完整的孢子项目或竞争成功, 在孢子之外的资金。DRP提供了一个独特的机会, 支持,并展示积极的机构支持,通过一个计划,是迅速响应新的 想法或倡议。此外,该计划植根于SPORE倡导的合作精神 研究者有将其他学科的研究者引入卵巢癌的广泛记录, 癌症研究。难民救济和重建方案的优势在于它有能力提供必要的财政支助, 访问整个SPORE内的所有关键专业知识和资源。这将使我们能够发展 合作,多研究者,多机构的研究项目与创新的支持,研究者- 启动的项目有可能发展成为可靠和富有成效的转化研究项目 这使得从基础和/或人口研究项目进入人类临床研究的道路 样本/患者人群。在过去的十年中,MD安德森卵巢孢子已经 支持来自22名调查员的DRP项目。这些研究人员共发表了470篇论文, 回顾了与卵巢癌相关的手稿。13名获奖者获得了同行评审的资金 作为PI、Co-PI或合作研究者。调查人员已经收到了来自三个 R 01,三个R21,三个CPRIT奖,两个国防部奖和四个OCRA奖。一 最近资助周期的获奖者刚刚获得卵巢癌研究联盟和 妇女癌症基金会。此外,三名前获奖者参加了完整的SPORE项目 完成一个DRP项目后。
英文摘要
Developmental Research Program SUMMARY/ABSTRACT The purpose of the Developmental Research Program (DRP) is to fund promising projects by investigators whose current work may not focus exclusively on ovarian cancer, but who propose highly innovative translational studies of ovarian cancer that could become full SPORE projects or compete successfully for funding outside of the SPORE. The DRP provides a unique opportunity for making available significant financial support, and for demonstrating active institutional support, through a program that is rapidly responsiveto new ideas or initiatives. Moreover, this program is rooted in a spirit of collaboration promoted by the SPORE investigators who have an extensive track record of bringing investigators from other disciplines into ovarian cancer research. The strength of the DRP rests in its ability to make available financial support needed to access all the critical expertise and resources within the entire SPORE. This will allow us to develop collaborative, multi-investigator, multi-institutional research projects with the support of innovative, investigator- initiated projects that have the potential to flourish into reliable and productive translational research projects that make a path from basic and/or population research projects into research focused on human clinical specimens/patient populations. Over the course of the past decade, the MD Anderson OvarianSPORE has supported DRP projects from 22 investigators. Collectively, these investigators have published 470 peer- reviewed manuscripts related to ovarian cancer. Thirteen of the recipients have received peer-reviewedfunding in ovarian cancer as either PI, Co-PI or Co-Investigator. The investigators have received funding from three R01s, three R21s, three CPRIT awards, two Department of Defense Awards and four OCRA awards. One awardee in the most recently funded cycle just received support from both the Ovarian Cancer Research Alliance and Foundation for Women’s Cancer. Additionally, three former awardees have participated in full SPORE projects after completing a DRP project.
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Career Enhancement Program
The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer
The University of Texas MD Anderson Cancer Center SPORE in Ovarian Cancer
DIRAS3 disrupts K-RAS clustering and signaling, enhancing autophagy and response to autophagy inhibition
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