HD2A Research Adoption Support Center (RASC)

总体：项目摘要/摘要 为响应美国国立卫生研究院RFA-DA-22-050，我们在此提出一项治愈数据2行动 研究采用支持中心(RASC)。RASC的主要目的是遏制服药过量的浪潮 通过领导一项科学驱动的支持活动，旨在有效地转化证据- 以药物使用障碍和疼痛为基础的干预。目前，服药过量的死亡人数不断上升。传播 实施(D&I)科学是弥补科学和公共卫生差距的方法论桥梁。 然而，D&I科学在应对阿片类药物流行方面的研究和利用不足。象征着 为了提高人们对D&I科学潜力的认识，将启动Hear D2a计划。该计划 有10-12个创新项目，除了RASC，还有两个额外的中心：建模和 经济资源中心和数据基础设施支持中心。RASC将优化和提升 整个HD2A计划的研发能力。在这个整体组件中，我们记录了RASC是如何 组织成四个协同和动态的核心：行政、物质使用执行支助 核心、疼痛实施支持核心和研究与评估核心。三个突出的具体目标 在整个RASC和其所有核心的战略排序如下：评估HD2a的当前状态 关于研发和创新研究能力的创新项目，并开发基于经验的循证目录 以及针对药物使用障碍和疼痛的新兴干预措施；协助创新项目如何 通过按需提供技术援助和使用创新的 实施支持计划，并制定SUD和疼痛干预D&I资源指南；最后， 推动HD2A创新项目朝着更大的可扩展性和可持续性方向发展。RASC是 由4名MPI领导，他们在物质使用和使用领域的D&I研究和实践方面有良好的记录 疼痛干预：麦戈文(斯坦福)，S.贝克尔(布朗)，W.贝克尔(耶鲁)和布朗(西北大学)。这个 MPI由互补的专家核心联席董事加入，并组建了一支无与伦比的 这些领域的高素质领导者-精心挑选、组织并随时准备提供必要的 在整个HD2A计划中提供实施支持。该RASC满足以下所有指定要求 在RFA中概述。这个RASC的不同之处在于我们的雄心壮志不仅是提高D&I能力 但影响的领域远远超出了HD2A倡议的范围。我们打算 提升药物使用和疼痛干预研究的D&I范式，从而确保无处不在的 最需要干预的人和社区公平地获得经证实的干预措施。

OVERALL: PROJECT SUMMARY/ABSTRACT In response to the National Institutes of Health RFA-DA-22-050, we herein propose a HEAL Data2Action Research Adoption Support Center (RASC). The main purpose of the RASC is to stem the tide of overdose death in the US by leading a scientifically-driven support endeavor designed to effectively translate evidence- based interventions for substance use disorders and pain. Presently, overdose death escalates. Dissemination and implementation (D&I) science is the methodological bridge to both the scientific and public health gaps. Yet D&I science is understudied and underutilized in response to the opioid epidemic. Emblematic of heightened awareness for D&I scientific potential, the HEAL D2A Program will be launched. The program features 10-12 Innovation Projects, and, in addition to the RASC, two additional centers: Modeling and Economic Resource Center and Data Infrastructure Support Center. The RASC will optimize and elevate the D&I capability of the overall HD2A program. In this OVERALL component, we document how the RASC is organized into four synergistic and dynamic cores: Administrative, Substance Use Implementation Support Core, Pain Implementation Support Core, and a Research & Evaluation Core. Three overarching specific aims are strategically ordered across the RASC and all its cores follows: To ASSESS the current state of the HD2A Innovation Projects on D&I research capability, and develop an empirically-based catalog of evidence-based and emerging interventions for substance use disorders and pain; to ASSIST on how Innovation Projects can improve D&I methods and measures through on demand technical assistance and the use of an innovative Implementation Support Plan, and to develop SUD and Pain Intervention D&I Resource Guides; and lastly, to ADVANCE the HD2A Innovation Projects toward greater potential for scalability and sustainment. The RASC is led by 4 MPIs with demonstrated track records of D&I research and practice in the fields of substance use and pain interventions: McGovern (Stanford), S. Becker (Brown), W. Becker (Yale) and Brown (Northwestern). The MPIs are joined by complementary expert core co-directors, and have assembled an unmatched roster of highly-qualified leaders in these fields—carefully selected, organized and ready to provide the necessary implementation support across the HD2A program. This RASC meets all the specified requirements as outlined in the RFA. What distinguishes this RASC is our bold ambition to enhance not only the D&I capability of the HEAL HD2A program, but to influence the field far beyond the confines of the HD2A initiative. We intend to elevate the D&I paradigm of substance use and pain intervention research, and thereby ensure ubiquitous and equitable access to proven interventions by the people and communities who need them the most.