Microelectrode Recordings from the Vagus Nerve in Awake Humans

辅助项目1摘要：清醒人类迷走神经的微电极记录 迷走神经是最长的脑神经，为颈部、胸部和腹部的结构提供感觉和运动神经支配，包括对心、肺、呼吸道和肠道的副交感神经支配。与交感神经系统不同的是，50年来，人类一直可以在交感神经系统中进行直接微电极记录，而到目前为止，还不可能直接记录副交感神经流出。我们开发了一种超声引导的方法，允许我们通过经皮插入清醒人类颈部的微电极直接从迷走神经进行记录。在这个辅助项目中，我们计划通过对人的迷走神经进行详细的神经生理学研究，并确定迷走神经刺激时激活的神经纤维，包括感觉和运动(包括副交感神经)轴突，来建立这种方法的初步数据。这可能会提供特定范围的刺激强度，以兴奋临床研究方案中的有髓和无髓神经纤维，如临床核心中所述。它还将为人类迷走神经的生理学提供前所未有的细节，并为未来新型束内神经接口的发展提供信息。

ANCILLARY PROJECT 1 Abstract: Microelectrode Recordings from the Vagus Nerve in Awake Humans The vagus nerve, the longest cranial nerve, supplies structures in the neck, thorax, and abdomen with sensory and motor innervation, including parasympathetic innervation to the heart, lungs, airways, and gut. Unlike the sympathetic nervous system, in which it has been possible to make direct microelectrode recordings in humans for >50 years, it has not been possible to record parasympathetic outflow directly – until now. We developed an ultrasound-guided approach that allows us to record directly from the vagus nerve via a microelectrode inserted percutaneously into the neck of awake humans. In this Ancillary Project, we plan to build upon our preliminary data from this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and identifying the nerve fibers activated during vagal nerve stimulation, both sensory and motor (including parasympathetic) axons. This may provide a specified range of stimulus intensities required to excite myelinated and unmyelinated nerve fibers in the Clinical Study Protocol as described in the Clinical Core. It will also provide unprecedented detail into the physiology of the human vagus nerve and inform future development of novel intrafascicular neural interfaces.