Mechanisms to promote vascular normalisation and barrier integrity

血管的生长和功能依赖于血管壁中单个细胞之间的运动和黏附的协调，然而控制这些行为的信号仍然未知。该项目将揭开疾病诱导的血管生长过程中细胞相互作用的精确机制。更好地了解这些细胞过程将有助于开发针对癌症和糖尿病等疾病的新型靶向疗法。

Growth and function of blood vessels is dependent on the coordination of movement and adhesion between individual cells in the vessel wall, however the signals controlling these actions remain unknown. This project will unravel the precise mechanisms by which cells interact during vessel growth induced by disease. A greater understanding of these cellular processes will allow for the development of novel targeted therapies for diseases including cancer and diabetes.