Training Grant in CVD Genetic Epidemiology

(申请人--S摘要) 心血管疾病的遗传基础及其相关表型 定义不明确。分子和统计学领域的进展 遗传学极大地提高了我们理解遗传病因的能力。 复杂的疾病，比如脑血管病。几项心血管疾病遗传流行病学研究 拥有丰富的具有良好特性的基因类型、环境和表型 可用的数据。人类基因组计划将拥有人类的序列 基因组DNA于2003年完成，目前已有丰富的数据和 用于进行与遗传和基因组贡献有关的分析的资源 心血管疾病。对科学家的需求很大，他们成功地 各种类型的数据(遗传、环境和表型)。遗传 流行病学家，在流行病学方法、统计学和 迫切需要遗传学来扩大这一新兴领域的研究机会 菲尔德。 这项为期五年的计划，如果获奖，将为3名博士后提供培训 研究员和1个博士后研究员职位。对博士后的需求 奖学金，基于该司博士项目的最近申请者， 正在增加。此外，我们目前拥有优秀的博士前和 符合以下条件的博士后候选人将有资格获得奖学金 提案得到了资金支持。节目？S一流的设施，大而多样 教职员工和广阔的研究机会提供了出色的培训 环境。 明尼苏达大学的两到三年奖学金项目提供 在遗传学的直接研究经验方面有出色的培训机会 流行病学与正规课程作业的强大课程相结合 研讨会。妇女和少数群体的参与是以下方面的高度优先事项 团契训练。培训的独特性在于其承诺 以家庭为基础的研究中现有研究的广度和深度 在CVD中，以及种群、分子和 统计遗传学。对合格的心血管疾病遗传流行病学家的需求是 紧急，以及培训科学家从事心血管疾病遗传学研究 流行病学将有助于进一步了解复杂的遗传 脑血管病的病因学。(摘要结束)

(Applicant?s Abstract) The genetic basis of cardiovascular diseases (CVD) and its related phenotypes is poorly defined. Advancements in the fields of molecular and statistical genetics have greatly enhanced our ability to understand the genetic etiology of complex diseases, like CVD. Several CVD genetic epidemiological studies have a wealth of well-characterized genotypic, environmental, and phenotypic data available. The Human Genome Project will have the sequence of human genomic DNA completed by 2003, an currently has abundance of data and resources to conduct analyses related to genetic and genomic contributions to CVD. There is a great demand for scientists that successfully integrate various types of data (genetic, environmental, and phenotypic). Genetic epidemiologist, rigorously trained in epidemiologic methods, statistics, and genetics are urgently needed to expand research opportunities in this emerging field. This five-year proposal, if awarded, will provide training for 3 pre-doctoral fellows and 1 post-doctoral fellowship positions. The demand for pre-doctoral fellowships, based on recent applicants to the Ph.D. program in the Division, is increasing. In addition, we currently have excellent pre-doctoral and post-doctoral candidates who would be eligible for a fellowship if the proposal is funded. The Program?s excellent facilities, large and diverse faculty, and broad research opportunities offer an outstanding training environment. The University of Minnesota two to three year fellowship program offers outstanding training opportunities in direct research experience in genetic epidemiology combined with a strong curriculum of formal course work and seminars. The participation of women and minorities is a high priority for fellowship training. The uniqueness of the training is the commitment of its faculty and the breadth and depth of existing research in family-based studies in CVD, and the combination of coursework in population, molecular, and statistical genetics. The need for qualified CVD genetic epidemiologists is urgent, and the training of scientists for research careers in CVD genetic epidemiology will help to further understanding of the complex genetic etiology of CVD. (End of Abstract)