DIET, INFLAMMATION, AND PERIODONTAL DISEASE

建议的研究目的是调查习惯性饮食摄入鱼类、海洋来源的n-3脂肪酸和总脂肪在改变牙周病风险和宿主炎症反应方面的作用。这项研究的主要目标是：(A)确定由食物频率问卷确定的更多的习惯性饮食摄入鱼类和海洋来源的n-3脂肪酸是否与中年男女牙周疾病的患病率、程度和严重程度的降低有关，(B)确定更多的鱼类和海洋来源的n-3脂肪酸的饮食摄入量是否源于在牙周沟液样本中测得的前列腺素E2和血栓素B2水平的降低，(C)确定鱼和海洋来源的n-3脂肪酸的习惯性饮食摄入量增加是否与血清中C反应蛋白的C反应水平降低有关，以及(D)确定总脂肪的习惯性饮食摄入量增加是否与牙周沟液中前列腺素E_2水平的升高有关。研究人群将是社区动脉粥样硬化风险研究(ARIC)，这是一项对美国四个社区的15,792名中年男性和女性进行的心血管疾病、亚临床动脉粥样硬化和相关风险因素的纵向调查。这项研究将利用以前收集的关于ARIC队列成员的日常或习惯饮食、牙周疾病的患病率、程度和严重程度以及局部和全身炎症介质和标记物水平的信息。这项拟议的研究将代表对饮食、牙周病和炎症介质的最大流行病学研究之一，并将提供关于牙周病和其他慢性炎症条件的潜在可改变危险因素的新数据。

The purpose of the proposed research is to investigate the role of habitual dietary intake of fish, n-3 fatty acids of marine origin, and total fat in modifying risk of periodontal disease and the host inflammatory response. The primary goals of this study are to: (a) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin, as determined by food frequency questionnaires, is associated with decreased prevalence, extent, and severity of periodontal conditions in a middle-aged biracial cohort of men and women, (b) determine whether greater dietary intake of fish and n-3 fatty acids of marine origin is originated with reduced levels of prostaglandin E2 and thromboxane B2 measured locally in samples of gingival crevicular fluid, (c) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin is associated with reduced levels of C-reactive of C-reactive protein measured in serum, and (d) determine whether greater habitual dietary intake of total fat is associated with increased levels of prostaglandin E2 measured in gingival crevicular fluid. The study population will be the Atherosclerosis Risk in Communities Study (ARIC), a longitudinal investigation of cardiovascular disease, subclinical atherosclerosis, and associated risk factors in a cohort of 15,792 middle-aged men and women in four U.S. communities This research will take advantage of previously collected information on usual or habitual diet, prevalence, extent, and severity of periodontal conditions and levels of local and systemic inflammatory mediators and markers in members of the ARIC cohort. The proposed research will represent one of the largest epidemiologic studies of diet, periodontal disease, and mediators of inflammation and will provide new dat concerning potentially modifiable risk factors for periodontal disease and other chronic inflammatory conditions.