DIET, INFLAMMATION, AND PERIODONTAL DISEASE

饮食、炎症和牙周疾病

• 批准号: 6644950
• 负责人: JAMES S PANKOW
• 金额: --
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644950
• 关键词: acute phase protein; clinical research; dietary constituent; dietary lipid; epidemiology; fish; human subject; inflammation; marine animal oil; nutrition related tag; omega 3 fatty acid; periodontium disorder; prostaglandin E; thromboxanes

The purpose of the proposed research is to investigate the role of habitual dietary intake of fish, n-3 fatty acids of marine origin, and total fat in modifying risk of periodontal disease and the host inflammatory response. The primary goals of this study are to: (a) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin, as determined by food frequency questionnaires, is associated with decreased prevalence, extent, and severity of periodontal conditions in a middle-aged biracial cohort of men and women, (b) determine whether greater dietary intake of fish and n-3 fatty acids of marine origin is originated with reduced levels of prostaglandin E2 and thromboxane B2 measured locally in samples of gingival crevicular fluid, (c) determine whether greater habitual dietary intake of fish and n-3 fatty acids of marine origin is associated with reduced levels of C-reactive of C-reactive protein measured in serum, and (d) determine whether greater habitual dietary intake of total fat is associated with increased levels of prostaglandin E2 measured in gingival crevicular fluid. The study population will be the Atherosclerosis Risk in Communities Study (ARIC), a longitudinal investigation of cardiovascular disease, subclinical atherosclerosis, and associated risk factors in a cohort of 15,792 middle-aged men and women in four U.S. communities This research will take advantage of previously collected information on usual or habitual diet, prevalence, extent, and severity of periodontal conditions and levels of local and systemic inflammatory mediators and markers in members of the ARIC cohort. The proposed research will represent one of the largest epidemiologic studies of diet, periodontal disease, and mediators of inflammation and will provide new dat concerning potentially modifiable risk factors for periodontal disease and other chronic inflammatory conditions.

本研究的目的是探讨鱼类、海洋来源的n-3脂肪酸和总脂肪在改变牙周病风险和宿主炎症反应中的作用。本研究的主要目标是：(a)确定通过食物频率问卷确定的习惯性饮食中更多地摄入鱼类和海洋来源的n-3脂肪酸是否与中年男女双种族队列中牙周病的患病率、程度和严重程度降低有关；(b)确定饮食中鱼类和海洋来源的n-3脂肪酸摄入量的增加是否与牙龈沟液样本中局部测量的前列腺素E2和血栓素B2水平的降低有关；(c)确定饮食中鱼类和海洋来源的n-3脂肪酸摄入量的增加是否与血清中c -反应蛋白水平的降低有关；(d)确定习惯性饮食中总脂肪摄入量的增加是否与牙龈沟液中前列腺素E2水平的升高有关。研究人群将是社区动脉粥样硬化风险研究（ARIC），这是一项针对心血管疾病、亚临床动脉粥样硬化和相关风险因素的纵向调查，研究对象是来自美国四个社区的15,792名中年男性和女性。这项研究将利用先前收集的关于日常或习惯饮食、患病率、程度、ARIC队列成员牙周状况的严重程度以及局部和全身炎症介质和标志物的水平。这项拟议的研究将代表饮食、牙周病和炎症介质的最大流行病学研究之一，并将提供有关牙周病和其他慢性炎症条件的潜在可改变危险因素的新数据。