Mechanisms responsible for neurogenic hypertension: a novel interaction between GABAergic modulation of amygdalo-hypothalamic pathways and microRNA regulation of renin

高血压的遗传模型将用于了解脑，神经系统和肾脏的相互作用。拟议中的研究将验证这样一种假设，即大脑特定区域的抑制性神经化学物质的破坏，会导致肾脏神经系统的更大激活，从而减少抑制分子，最终导致负责升高血压的激素系统的更大激活。

A genetic model of hypertension will be used to understand the interrelated role of the brain, nervous system and kidney. The proposed studies will test the hypothesis that disruption of inhibitory neurochemicals in specific regions of the brain, leads to greater nervous system activation of the kidney, which in turn decreases an inhibitory molecule, ultimately resulting in greater activation of a hormonal system responsible for raising blood pressure.