Mechanisms and targets of antibody-complement interactions that neutralize malaria

我们的项目旨在确定免疫机制，从蚊子接种的那一刻起，在感染建立之前，中和疟疾，以防止疟疾疾病的发展。此外，我们将发现保护性免疫反应的特定靶点。我们期望这个项目将为我们对恶性疟原虫疟疾的人类免疫知识提供重大的新进展，恶性疟原虫疟疾是世界上最重要的死亡和发病原因之一，我们将利用这些知识

Our project aims to identify immune mechanisms that neutralize malaria from the moment of inoculation by a mosquito, before infection can become established to prevent the development of malaria disease. Furthermore, we will discover specific targets of protective immune responses. We expect this project will provide major new advances in our knowledge of human immunity to P. falciparum malaria, one of the world’s most significant causes of mortality and morbidity, and we will use this knowledge