B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics

B 细胞和三级淋巴结构：癌症治疗的新兴靶点

• 批准号: 10754008
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10754008
• 关键词: Address; Antibodies; Antibody Response; Autoantigens; Autoimmune Diseases; Autoimmunity; B-Lymphocyte Subsets; B-Lymphocytes; British Columbia; Cancer Burden; Cancer Patient; Career Choice; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Communities; Data; Discipline; Disease; Economic Burden; Educational workshop; Emotional; Fostering; Future; Glean; Goals; Growth; Immune response; Immunology; Immunotherapy; Industry; Knowledge; Knowledge acquisition; Learning; Malignant Neoplasms; Methodology; Monoclonal Antibody Therapy; Outcome; Participant; Patients; Persons; Process; RNA vaccine; Research; Research Personnel; Role; Scientist; Series; Severities; Shapes; Societies; Technology; Therapeutic; Vaccines; Work; cancer immunotherapy; career; clinical practice; clinical translation; combat; effective therapy; forging; improved; insight; interest; meetings; member; multidisciplinary; novel; pandemic disease; patient response; posters; response; symposium; tertiary lymphoid organ; therapy resistant; training opportunity; tumor; tumor progression; vaccine-induced antibodies; virtual

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics, organized by Drs. Tullia Bruno, Brad Nelson, Daniel Hollern and Marie-Caroline Dieu-Nosjean. The conference will be held in Whistler, British Columbia from October 1-4, 2023. With vaccines, antibody-based immunotherapy, and scientific discoveries of B cell functional mechanisms, major breakthroughs are happening surrounding B cells. This marks a field of research that is poised for exponential growth in acquisition of knowledge and effective therapies. In particular, the novel insights into B cell biology have revealed conserved aspects across disease; for example, B cells are now recognized as critical players in Tertiary Lymphoid Structures (TLS) for both cancer patient response to immunotherapy and the severity of autoimmune disease. Likewise, B regulatory cells use mechanisms to protect from autoimmunity that are common to the mode by which they fuel cancer’s progression and resistance to therapy. By examining data across disciplines, scientists are gleaning major insights that shape the forward progression of the entire field of research. To foster the process of breakthroughs in the field of B cell research, we have established the B Cells in Cancer Consortium (BC3) to bring together this ever-growing community, and as expected, there is high interest. Specifically, our first year has built a constituency of more than 500 scientists for our virtual seminar series. This signifies a likelihood for an even larger audience given the expansive pace of immunology research driven by the global pandemic. With mRNA vaccines and monoclonal antibody therapies being a topic of high exposure, people are more informed than ever on B cell biology. This inaugural Keystone Symposia conference will be the first opportunity for this nascent field to meet together, providing a unique opportunity to forge new connections and catalyze future research into the importance of B cell function in cancer.

摘要 请求支持题为B细胞和第三类淋巴结构的Keystone研讨会： 癌症治疗中的新兴目标，由Tullia Bruno博士、Brad Nelson博士、Daniel Hollern博士和 玛丽-卡罗琳·迪欧-诺斯金。大会将于2023年10月1日至4日在不列颠哥伦比亚省惠斯勒举行。 随着疫苗、基于抗体的免疫疗法和B细胞功能机制的科学发现，主要 B细胞周围正在取得突破性进展。这标志着一个研究领域将呈指数级增长。 在获得知识和有效治疗方面的增长。特别是，对B细胞生物学的新见解 揭示了疾病中保守的方面；例如，B细胞现在被认为是 三级淋巴结构(TLS)对癌症患者免疫治疗反应和病情严重程度的影响 自身免疫性疾病。同样，B调节细胞使用机制来保护自身免疫，这是 共同的模式，他们助长癌症的进展和抵抗治疗。通过检查数据 在不同的学科中，科学家们正在收集影响整个领域向前发展的重要见解 研究。为了促进B细胞研究领域的突破，我们建立了B细胞 在癌症联盟(BC3)将这个不断增长的社区聚集在一起，正如预期的那样，有很高的 利息。具体地说，我们的第一年为我们的虚拟研讨会建立了500多名科学家的支持者 系列片。这意味着，考虑到免疫学研究的广泛步伐，可能会有更多的受众 在全球大流行的推动下。随着信使核糖核酸疫苗和单抗治疗成为一个高度关注的话题 暴露后，人们对B细胞生物学的了解比以往任何时候都要多。首届Keystone研讨会会议 将是这一新兴领域相聚的第一次机会，为打造新的 连接并催化未来对B细胞功能在癌症中的重要性的研究。