Feasibility of implementing time-restricted eating in women with mild cognitive impairment

项目摘要 阿尔茨海默病(AD)是一种无法治愈的神经退行性疾病，影响着650万美国人 65岁。目前，尚无药物疗法可预防AD或显著延缓病情恶化。 痴呆症。与男性相比，女性患AD的终身风险是男性的两倍，因此研究这一点至关重要 在妇女中发展疾病进展和制定干预措施。临床研究表明，昼夜节律和 睡眠障碍与认知障碍和阿尔茨海默病的临床前标志有关。因此，治疗学 改善昼夜节律和睡眠可能会阻止AD的发展和进展。无数的临床前 临床研究表明，限时进食(Tre)，一种符合昼夜节律的行为干预 将食物摄取到活动期，改善心脏代谢的健康结果。最近的研究表明， Tre还可以改善认知能力。因此，TrE是一种很有前途的AD干预策略，但还没有研究表明这一点 研究了它在改善认知障碍个体认知方面的有效性。我们漫长的第一步- 研究TRE认知效能的术语目标是确定TRE在患有以下疾病的人群中是否可行 认知障碍。这项可行性研究将研究实施为期8周的10小时培训计划。 对绝经后妇女轻度认知障碍(MCI)的干预。我们将招募15名女性 来自肯塔基大学正在进行的认知老化纵向研究的MCI。认知障碍， 睡眠和活动节律、饮食组成、新陈代谢评估、身体组成和人体测量 将在基线和为期8周的TRE干预后对措施进行评估。在研究期间， 第一餐和最后一餐的时间将通过短信系统从参与者那里收集，我们将 发展起来的。参与者将被指示在10小时的进食窗口进食，并在晚上禁食。初级阶段 这项研究的结果将是遵守TRE方案。这项试点研究还将提供 关于TRE对认知的影响的初步数据，这对于推动未来的随机研究是必不可少的 临床疗效试验。

Project Summary Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting 6.5 million Americans above the age of 65. Currently, no pharmacological therapy prevents AD or markedly slows the progression to severe dementia. Women have twice the lifetime risk of developing AD compared to men, so it is critical to study disease progression and develop interventions in women. Clinical studies show that circadian rhythm and sleep disruption are associated with cognitive impairment and preclinical markers of AD. Thus, therapeutics that improve circadian rhythms and sleep may prevent AD development and progression. Numerous preclinical and clinical studies have shown that time-restricted eating (TRE), a circadian behavioral intervention that aligns food intake to the active phase, improves cardiometabolic health outcomes. Recent studies have shown that TRE can also improve cognition. Thus, TRE is a promising intervention strategy for AD, but no study has investigated its efficacy at improving cognition in cognitively impaired individuals. A first step toward our long- term goal of studying TRE efficacy for cognition is to determine whether TRE is feasible in a population with cognitive impairment. This feasibility study will examine the implementation of an 8-week 10-h TRE intervention in postmenopausal women with mild cognitive impairment (MCI). We will recruit 15 women with MCI from an ongoing longitudinal study of cognitive aging at the University of Kentucky. Cognitive impairment, sleep and activity rhythms, diet composition, metabolic assessment, body composition, and anthropometric measures will be assessed at baseline and after the 8-week TRE intervention. For the duration of the study, the times of first and last meals will be collected from participants with an SMS texting system that we developed. Participants will be instructed to eat during a 10-h eating window and fast at night. The primary outcome of this study will be adherence to the TRE protocol regimen. This pilot study will also provide preliminary data about the effects of TRE on cognition, which are essential for powering a future randomized clinical efficacy trial.