The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care (CITEC) - Administrative Core

摘要： 发生在上皮组织中的癌症占所有病例的80 - 90%。许多上皮癌可以预防或治愈 通过检测和治疗癌前病变和早期疾病。许多POC技术已经表明， 有望改善癌症筛查和上皮癌前病变和癌症的早期检测，包括体外和体内检测。 活体成像工具和分子传感器。然而，POC技术的开发和转化因以下原因而放缓： 存在多种技术和临床障碍。中心的创新和翻译点的护理技术， 公平癌症护理（CITEC）旨在提供“一站式购物”以解决这些障碍。CITEC将支持和 加快开发、提供和公平使用负担得起、有效和可获得的POC技术， 和/或检测上皮癌前病变和早期癌症。行政核心将提供全面的项目监督， 管理，以确保所有CITEC核心在高水平上运行，核心有效协作，以实现整体 CITEC的目标，CITEC是响应和协同的整体POCTRN网络的目标。 行政核心的首要目标是建立和管理行政结构、治理政策， 决策、预算管理、冲突解决流程和中心的沟通计划。的 CITEC计划将由CITEC指导委员会监督，该委员会由PD/PI和具有同等资格的核心共同负责人组成。 投票权CITEC指导委员会将审查核心和个别项目的进展情况， 协议，确定技术进步的障碍，选择克服这些障碍的战略，并确定机会 用于共享在各个项目中开发的技术和工具。行政核心也将有主要的 负责与NIH的互动，并将与NIH合作，以推进实现POCTRN目标的努力。 行政核心的第二个目标是与CITEC合作，不断评估和改进CITEC。 领导核心收集和分析数据，以确定优化CITEC活动影响的挑战。到 为实现这一目标，行政核心将协助CITEC核心建立多学科伙伴关系;确保包容性 一个由不同的合作伙伴和利益攸关方组成的社区;以及评估业绩和指导业绩改进。 咨询委员会将制定审查机制，以确保项目资源得到有效利用， 开发、转化和公平实施POC技术，以改善癌症筛查和早期诊断， 侦测 AC将成立外部咨询委员会; CITEC绩效数据将与外部咨询委员会共享 委员会，并根据他们的反馈意见，确保CITEC从事有效的持续质量改进。 简而言之，行政核心将支持CITEC成员之间强有力、富有成效和高效的互动， 受资助的调查人员、POCTRN网络和相关利益攸关方。

Abstract: Cancers arising in epithelial tissue account for 80‐90% of all cases. Many epithelial cancers could be prevented or cured by detecting and treating pre‐cancerous lesions and early stage disease. A number of POC technologies have shown promise to improve cancer screening and early detection of epithelial precancer and cancer, including both in vitro and in vivo imaging tools, and molecular sensors. However, development and translation of POC technologies are slowed by multiple technical and clinical barriers. The Center for Innovation and Translation of Point‐of‐Care Technologies for Equitable Cancer Care (CITEC) is structured to offer “one‐stop shopping” to address these barriers. CITEC will support and accelerate the development, delivery and equitable use of affordable, effective and accessible POC technologies to screen and/or detect epithelial precancer and early cancer. The Administrative Core will provide overall project oversight and management to ensure that all CITEC cores function at a high level, that cores collaborate effectively to achieve the overall goals of CITEC, and that CITEC is responsive to and synergistic with the goals of the overall POCTRN network. The first aim of the Administrative Core is to establish and manage the administrative structure, governance policies, decision making, budget management, and conflict resolution processes and communications plans for the Center. The CITEC program will be overseen by a CITEC Steering Committee, consisting of the PD/PIs and co‐leads of Cores with equal voting rights. The CITEC Steering Committee will review progress of cores and individual projects, develop collaborative protocols, identify technological impediments to progress, select strategies to surmount them and identify opportunities for sharing techniques and tools developed within individual projects. The Administrative Core will also have primary responsibility for interactions with NIH and will work with NIH to advance efforts to reach the goals of POCTRN. The second aim of the Administrative Core is to work to continuously evaluate and improve CITEC, partnering with the leadership of the Cores to gather and analyze data to identify challenges in optimizing the impact of CITEC activities. To achieve this aim, the Administrative Core will assist CITEC Cores to build multidisciplinary partnerships; to ensure inclusion of a diverse community of partners and stakeholders; and to evaluate performance and guide performance improvement. The AC will develop review mechanisms to ensure that project resources are used effectively to accelerate the development, translation and equitable implementation of POC technologies to improve cancer screening and early detection. The AC will establish an External Advisory Committee; CITEC performance data will be shared with the External Advisory Committee and, with their feedback, will ensure that CITEC engages in effective continuous quality improvement. In short, the Administrative Core will support robust, productive and efficient interactions between CITEC members, funded investigators, the POCTRN network and relevant stakeholders.