Training in Systems Pharmacology and Toxicology (T-SPaT)

项目摘要/摘要 在过去的几十年里，我们对细胞与药物和毒素相互作用机制的了解 由于新的分子分析技术和基因组方法的应用而爆炸。因此， 药理学和毒理学学科研究生教育的重点需要从 一种系统的观点，博士生受到全面的培训，这样他们就可以 制定一项战略，不仅在分子、细胞和组织层面解决重要的生物学问题 而且在整个动物层面上也是如此。系统药理学和毒理学描述了一个研究领域，它考虑到 对毒品行为的广泛看法。使用活体动物模型的系统方法对于确定疗效是必要的， 候选药物的安全性和药效学/药动学概况但学生短缺 在这方面受过训练。本系统药理学和毒理学(T-SPAT)培训计划是为 正在攻读研究生二年级的博士生在美国攻读学位论文研究项目 药理科学。实习生(2/年，最多2年的支持)和33名计划教职员工来自 跨学科生物医学研究生项目(GPIBS)和医学博士项目。T-Spat 该计划将培训学生使用体内方法来回答相关的药理学和 毒理学，重点研究新陈代谢、药物设计、药效学、药代动力学和信号传递。 T-SPAT计划的基本原理是，这种类型的培训将为学生提供更广泛的 药理学和毒理学的观点，将使他们更好地准备进行安全、道德和严格的 作为药理科学领域多学科研究团队的领导者。我们将整合T- 我们在小石城地区的研究生培训地点已经在积极开展博士培训计划，其中包括 阿肯色州UAMS医学院、药剂学和公共卫生学院的教员/科学家 儿童医院校园，以及食品和药物管理局资助的国家毒理学中心 研究。T-SPAT的独特重点是用体内药理学和毒理学系统进行训练 方法和概念。T-SPAT的目标是提供活体药理学和毒理学培训 这是对学生在家庭项目中接受的细胞和分子训练的补充。培训 课程包括药理学、毒理学、生理学、药代动力学、新陈代谢、 生物统计学、拨款撰写、负责任的研究和实验室研究 人类疾病的活体模型。T-SPAT计划还将提供强大的指导、广泛的网络、 并通过其方案活动为受训人员提供教学和领导机会。

PROJECT SUMMARY/ABSTRACT Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Training in Systems Pharmacology and Toxicology (T-SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and 33 Program faculty are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences (GPIBS) and the MD/PhD Program. The T-SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for the T-SPaT program is that this type of training will provide students with a much broader perspective on pharmacology and toxicology that will better prepare them to conduct safe, ethical and rigorous research as leaders of multidisciplinary research teams in the pharmacological sciences. We will integrate T- SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children’s Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of T-SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of T-SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The T-SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.