Systems Pharmacology and Toxicology Training Program

系统药理学和毒理学培训计划

• 批准号: 10166861
• 负责人: Paul L Prather
• 金额: $ 15.51万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166861
• 关键词: Pharmacology and Toxicology; System; Training Programs

Project Summary/Abstract: Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Systems Pharmacology and Toxicology (SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and training faculty (30 mentors and 4 teachers) are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences and the MD/PhD Program. The SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for SPaT is that this type of training provides students with a much broader perspective on pharmacology and toxicology that better prepares them to be leaders of multi-disciplinary research teams in the pharmacological sciences. We will integrate SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children's Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.

项目概要/摘要： 在过去的几十年里，我们对细胞与药物和毒素相互作用的机制的了解， 由于新的分子分析技术和基因组学方法的应用，因此 药理学和毒理学学科研究生教育的重点需要从 简化论者认为，系统的方法，其中博士生得到全面的培训，使他们能够 制定解决重要生物学问题的战略，不仅在分子、细胞和组织水平上 而且是在整个动物的水平上。系统药理学和毒理学描述了一个研究领域， 对毒品作用的广泛看法。使用体内动物模型的系统方法对于建立功效是必要的， 候选药物的安全性和药效学/药代动力学特征，但学生短缺 在这方面受过训练。本系统药理学和毒理学（SPaT）计划是专为博士生 在他们的研究生学习的第二年，在药理学科学进行论文研究项目。 受训人员（每年2名，最多支持2年）和培训教师（30名导师和4名教师）来自 跨学科生物医学科学研究生课程和MD/PhD课程。SPaT计划 将培训学生使用体内方法来回答药理学和毒理学中的相关问题 重点是代谢、药物设计、药效学、药代动力学和信号传导。的理由 对于SPaT来说，这种类型的培训为学生提供了更广阔的药理学视角， 毒理学，更好地准备他们成为药理学领域多学科研究团队的领导者 以理工科为重我们将把SPaT整合到已经在我们的研究生培训基地活跃的博士培训计划中， 小石城地区，包括教师/科学家在医学院，药学和公共卫生上的 UAMS，阿肯色州儿童医院校园，以及食品和药物管理局资助的国家 毒理学研究中心。SPaT的独特重点是体内系统药理学培训 和毒理学方法和概念。SPaT的目的是提供体内药理学和 毒理学培训，补充学生在家中接受的细胞和分子培训 程序.培训计划包括药理学、毒理学、生理学、 药代动力学、代谢、生物统计学、资助撰写和负责任的研究行为，沿着 使用人类疾病体内模型的实验室研究。SPaT计划还将提供强大的 指导，广泛的网络，以及教学和领导的机会，其学员通过其 方案活动。