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Systems Pharmacology and Toxicology Training Program

系统药理学和毒理学培训计划

基本信息

批准号：
10394415
负责人：
Paul L Prather
金额：
$ 16.82万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10394415
关键词：
Pharmacology and Toxicology System Training Programs

项目摘要

Project Summary/Abstract: Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Systems Pharmacology and Toxicology (SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and training faculty (30 mentors and 4 teachers) are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences and the MD/PhD Program. The SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for SPaT is that this type of training provides students with a much broader perspective on pharmacology and toxicology that better prepares them to be leaders of multi-disciplinary research teams in the pharmacological sciences. We will integrate SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children's Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.

项目概要/摘要：在过去的几十年里，我们对细胞与药物和毒素相互作用的机制的了解，由于新的分子分析技术和基因组学方法的应用，因此药理学和毒理学学科研究生教育的重点需要从简化论者认为，系统的方法，其中博士生得到全面的培训，使他们能够制定解决重要生物学问题的战略，不仅在分子、细胞和组织水平上而且是在整个动物的水平上。系统药理学和毒理学描述了一个研究领域，对毒品作用的广泛看法。使用体内动物模型的系统方法对于建立功效是必要的，候选药物的安全性和药效学/药代动力学特征，但学生短缺在这方面受过训练。本系统药理学和毒理学（SPaT）计划是专为博士生在他们的研究生学习的第二年，在药理学科学进行论文研究项目。受训人员（每年2名，最多支持2年）和培训教师（30名导师和4名教师）来自跨学科生物医学科学研究生课程和MD/PhD课程。SPaT计划将培训学生使用体内方法来回答药理学和毒理学中的相关问题重点是代谢、药物设计、药效学、药代动力学和信号传导。的理由对于SPaT来说，这种类型的培训为学生提供了更广阔的药理学视角，毒理学，更好地准备他们成为药理学领域多学科研究团队的领导者以理工科为重我们将把SPaT整合到已经在我们的研究生培训基地活跃的博士培训计划中，小石城地区，包括教师/科学家在医学院，药学和公共卫生上的 UAMS，阿肯色州儿童医院校园，以及食品和药物管理局资助的国家毒理学研究中心。SPaT的独特重点是体内系统药理学培训和毒理学方法和概念。SPaT的目的是提供体内药理学和毒理学培训，补充学生在家中接受的细胞和分子培训程序.培训计划包括药理学、毒理学、生理学、药代动力学、代谢、生物统计学、资助撰写和负责任的研究行为，沿着使用人类疾病的体内模型的实验室研究。SPaT计划还将提供强大的指导，广泛的网络，以及教学和领导的机会，其学员通过其方案活动。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins.

DOI：
10.1371/journal.pone.0185542
发表时间：
2017
期刊：
PloS one
影响因子：
3.7
作者：
Parajuli N;Shrum S;Tobacyk J;Harb A;Arthur JM;MacMillan-Crow LA
通讯作者：
MacMillan-Crow LA

Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity.

耳蜗中药物代谢酶和转运蛋白的表达：对药物输送和耳毒性的影响。

DOI：
10.1016/j.heares.2019.05.002
发表时间：
2019
期刊：
Hearing research
影响因子：
2.8
作者：
Kennon-McGill,Stefanie;Clemens,MelissaM;McGill,MitchellR
通讯作者：
McGill,MitchellR

The link between immunity and hypertension in the kidney and heart.

DOI：
10.3389/fcvm.2023.1129384
发表时间：
2023
期刊：
FRONTIERS IN CARDIOVASCULAR MEDICINE
影响因子：
3.6
作者：
Benson, Lance N.;Guo, Yunping;Deck, Katherine;Mora, Christoph;Liu, Yunmeng;Mu, Shengyu
通讯作者：
Mu, Shengyu

Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?