The PET Radiotracer Translation and Resource Center (PET-RTRC)

总体项目摘要 在我们的国家生物医学成像和生物工程中心（NCBIB）的更新申请中，PET 放射性示踪剂和翻译中心（PET-RTRC），我们的目标是进一步加强该中心作为一个国家 资源，利用专业知识在华盛顿大学和Mallinckrodt放射学研究所在 PET放射性示踪剂的设计、开发、生产、培训和传播。与研究合作 在全国和欧洲研究炎症的分子和细胞过程的组织 在疾病方面，我们将进一步加强新型PET放射性示踪剂的开发和推广， 改变生物医学研究和促进人类健康。在此过程中，我们将加强基础， 推动PET-RTRC向前发展并维持其长期运营。为了实现我们的目标，我们将 以下具体目标： 目标1：为满足合作项目的科学需求， 研究与开发项目（TR& D 1-3）将建立在他们的成功创新，在目前的 资助周期，以开发针对炎症不同成分的放射性示踪剂，它们的动态变化， 以及诸如炎性小体激活（TR&D 1：鞘氨醇-1-磷酸受体-2）的后果， 单核细胞/巨噬细胞运输（TR&D 2：趋化因子C受体2/CD 163）和诱导线粒体 应激（TR&D 3：线粒体活性氧）。目标2：鉴于清洁生产作为技术的重要性 我们将进一步加强各个研发部门与其各自的 通过纳入加强跨中心沟通的战略、更有力的培训机会， 优化图像分析和数据管理，促进知识产权共享。目标3： 技术培训和传播核心扩大了其在当前赠款周期的成功， 培训和传播机会。在培训部分，中心的所有讲习班和研讨会将 以现场/远程混合模式呈现，将通过监考的“如何”视频提供个性化培训 将实施更多的外联举措， 其他P41中心，内部WU培训赠款/计划和传统上服务不足的大学。新 我们传播工作的创新将提高我们服务项目的能力， 和人类研究。行政核心将继续提供必要的管理监督， PET-RTRC的有效运作，以实现其科学、培训和传播目标。 成功完成拟议的续期申请将进一步推动PET-RTRC作为国家 资源，以促进研究，这将增加我们对疾病的分子基础的理解，从而 为新的诊断和治疗范例提供框架，从而改善人类健康。

Overall Project Summary In this renewal application of our National Center for Biomedical Imaging and Bioengineering (NCBIB), the PET Radiotracer and Translation Center (PET-RTRC), our objective is to further fortify the Center as a national resource that leverages the expertise at Washington University and the Mallinckrodt Institute of Radiology in PET radiotracer design, development, production, training and dissemination. In collaboration with research groups throughout the country and in Europe who are studying molecular and cellular processes of inflammation in disease, we will further enhance the development and dissemination of novel PET radiotracers needed to transform biomedical research and advance human health. In the process we will strengthen the foundation for propelling the PET-RTRC forward and sustaining its long term operation. To fulfill our objective we will address the following Specific Aims: Aim 1: In responding to the scientific needs of the Collaborative Projects (CPs), the three Technological Research & Development Projects (TR&Ds 1-3) will build upon their successful innovations during the current funding cycle to develop radiotracers that target different components of inflammation, their dynamic variation, and consequences such as inflammasome activation (TR&D 1: sphingosine-1-phosphate receptor-2), monocyte/macrophage trafficking (TR&D 2: chemokine C receptor 2/CD163) and the induction of mitochondrial stress (TR&D 3: mitochondrial reactive oxygen species). Aim 2: Given the importance of the CPs as technology drivers, we will further enhance the “push-pull” interaction between the individual TR&Ds and their respective CPs by including strategies that enhance cross-site communication, more robust training opportunities, optimized image analysis and data management and facilitated sharing of intellectual property. Aim 3: The Technology Training and Dissemination Core expands its success in the current grant cycle to offer robust training and dissemination opportunities. In the training component, all Center workshops and seminars will be presented in a hybrid onsite/remote mode, individualized training will be offered via proctored “how to” videos on key topics and additional outreach initiatives will be implemented that are geared towards interactions with other P41 Centers, internal WU training grants/programs and traditionally underserved universities. New innovations in our dissemination efforts will increase the capabilities of our Service Projects for both pre-clinical and human studies. The Administration Core will continue to provide the managerial oversight necessary for the efficient operation of the PET-RTRC so that it meets its scientific, training and dissemination objectives. Successful completion of the proposed renewal application will further propel the PET-RTRC as a national resource to facilitate research that will increase our understanding of the molecular basis of disease, thus providing the framework for novel diagnostic and therapeutic paradigms leading to improved human health.