Core Grant for Vision Research - Core 3

核心3：动物模型和眼器官培养 摘要 动物模型和眼器官文化核心的目标是促进动物和眼器官的使用 通过合格的NEI资助的研究人员来研究视觉功能和视觉疾病的文化。我们还帮助非 使调查人员有资格生成初步数据，以支持寻求NIH资金的提案。这是 通过提供从啮齿动物到一系列物种的互补动物模型的专业知识来实现 对于非人类灵长类动物，包括自发性和实验性的青光眼模型，视网膜 变性、眼血管疾病、眼药理学和毒理学及感染性疾病 包括动物处理和麻醉，更重要的是，提供活体动物研究的替代品 包括眼器官培养。我们提供视觉评估所需的专业知识和设备 系统结构和功能包括ERG，多焦和模式ERG，VEP，OCT，视网膜成像， 眼压测量和流出设备以及流出途径的确定。由于拥有独特的专业知识和访问权限 横跨翻译光谱的模式物种，这个核心产生了广泛的影响，促进了 跨学科和跨机构的愿景研究，以支持NEI的使命。

CORE 3: ANIMAL MODELS AND EYE ORGAN CULTURE ABSTRACT The goal of the Animal Models and Eye Organ Culture Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non- qualifying investigators in generating preliminary data, in support of proposals seeking NIH funding. This is accomplished by providing expertise in complementary animal models across a range of species from rodents to non-human primates (NHPs) and including spontaneous and experimental models of glaucoma, retinal degeneration, ocular vascular disease ocular pharmacology and toxicology and infectious diseases and includes animal handling and anesthesia and, importantly, provision of alternatives to live animal research including eye organ culture. We provide expertise and equipment necessary for the evaluation of visual system structure and function including ERG, multifocal and pattern ERG, VEP, OCT, retinal imaging, tonometry and outflow facility and outflow pathway determination. As a result of unique expertise and access to model species spanning the translational spectrum, this core has had a broad impact, facilitating interdisciplinary and inter-institutional vision research in support of the NEI’s mission.