Research Outcomes Accelerating Discoveries for Medical Applications and Practice

描述（由申请人提供）：作为从事太平洋盆地生物医学和生物行为研究的主要美国高等教育机构，夏威夷大学马诺阿分校（UHM）寻求国家研究资源中心的少数民族机构研究中心（RCMI）计划的持续支持。通过建立跨学科转化研究管道（TRIP），进一步发展生物医学和健康方面的卓越研究，旨在将基础科学与临床医学联系起来，将研究发现与创新医疗应用相结合，并在社区参与下发展改进的病人护理实践。指定的研究成果加速医学应用和实践的发现（路线图），2006-2011周期的UHM RCMI计划将通过创建跨学科合作研究网络，采用临床和转化科学的新兴技术，拥抱NIH路线图的精神和原则。具体而言，拟议的生物医学成像和生物工程及生物活性营养素研究活动，以及热带传染病检测和预防以及生物统计和计算机支助服务的核心设施，将在很大程度上依赖于基础科学家和临床医生之间的密切跨学科合作和知识交流，以应用人类生物学知识和物理学、数学、生理学、生物化学、分子生物学和微生物学，开发新的和改进的针对特定疾病的诊断测试、治疗干预措施和预防战略，以解决区域和国家重要的健康差距问题。此外，这些活动的设计将密切补充RCMI临床研究中心（RCRII）的基础科学、临床和面向患者的活动，以及其他ncrr资助的项目，包括太平洋早期人类发展研究中心（CCRE）、太平洋新发传染病研究中心（COBRE）、免疫和神经疾病的细胞基础（INBRE）以及基因、细胞和系统水平的情感和认知（SNRP）。基础科学、临床医学和社区参与的三角测量也将有助于UHM更好地充分参与RCMI转化研究网络（RTRN），并最终获得临床和转化科学奖（CTSA）。为每项研究和与研究有关的活动确定了强有力的领导。五名有前途的基础科学初级教师与临床科学家配对，进行高度创新、假设驱动的跨学科转化研究项目，这些项目极有可能获得独立资助。最后，正在开发和扩大互补的技术核心，以便在争取NIH的主流校外研究和培训资金方面取得更大的成功。

DESCRIPTION (provided by applicant): As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Program, of the National Center for Research Resources, to further develop research excellence in biomedicine and health by establishing a translational research interdisciplinary pipeline (TRIP) aimed at linking basic sciences and clinical medicine, integrating research discoveries with innovative medical applications, and developing improved patient-care practices with community participation. Designated Research Outcomes Accelerating Discoveries for Medical Applications and Practice (ROADMAP), the UHM RCMI Program for the 2006-2011 cycle will embrace the spirit and tenets of the NIH Roadmap by creating interdisciplinary collaborative research networks employing emerging technologies for clinical and translational sciences. Specifically, the proposed research activities on biomedical imaging and bioengineering and bioactive nutrients, as well as the core facilities for tropical infectious diseases detection and prevention and for biostatistics and computer support services, will rely heavily on close interdisciplinary collaborations and intellectual exchange between basic scientists and clinicians, in applying knowledge of human biology and fundamental principles of physics, mathematics, physiology, biochemistry, molecular biology and microbiology to develop novel and improved disease-specific diagnostic tests, therapeutic interventions and preventive strategies for health disparities of regional and national importance. Moreover, these activities will be designed to closely complement the basic science, clinical and patient-oriented activities of the RCMI Clinical Research Center (RCRII) and those of other NCRR-funded initiatives, including the Pacific Research Center for Early Human Development (CCRE), Pacific Center for Emerging Infectious Diseases Research (COBRE), Cellular Basis of Immunological and Neurological Disease (INBRE), and Emotion and Cognition on Gene, Cell and Systems Levels (SNRP). The triangulation of basic science, clinical medicine and community participation will also serve to better position UHM to participate fully in the RCMI Translational Research Network (RTRN) and to ultimately secure a Clinical and Translational Sciences Award (CTSA). Strong leadership has been identified for each of the research and research-related activities. And five promising basic-science junior faculty have been paired with clinician scientists to conduct highly innovative, hypothesis-driven, interdisciplinary translational research projects that have a high likelihood of leading to independent funding. Finally, complementary technical cores are being developed and expanded to achieve greater success in competing for mainstream extramural NIH funding for research and training.