Impact of Exposure to Perfluoroalkyl Substances on Weight Loss: A Pilot Study of Hispanic Children with Overweight/Obesity Participating in a Community-based Weight Loss Intervention Program

儿童肥胖是一种公共健康危机，对西班牙裔儿童的影响不成比例。我们建议进行一项初步研究 超重/肥胖西班牙裔人群中全氟烷基物质(PFAS)与体重减轻的关系 参加了为期10周的减肥干预的儿童。重点将放在干预前和干预后 干预前PFAS暴露对体重、血压和血脂的影响。 这一结果将对确定影响儿童体重减轻的因素产生影响，并将为 为R01应用程序支持的更明确和更大规模的调查奠定基础。 我们的建议解决了一个关键的研究缺口。尽管在儿童中广泛接触全氟辛烷磺酸， 肥胖效应的实验证据，以及越来越多的流行病学结果表明 对于肥胖效应，暴露于全氟辛烷磺酸对儿童体重减轻的影响尚有待评估。此外， 还没有研究集中在西班牙裔人群中的PFAS和减肥，因为西班牙裔人群的肥胖程度更高 比非西班牙裔儿童风险更大。这项建议建立在Vidas Activas y Familias Saludables(Vale)研究的基础上， 根据文化定制的为期10周的社区减肥干预措施，显著减少了儿童的 体重指数、体脂百分比、血压和血清非高密度脂蛋白。 我们将在淡水河谷研究中测量12个遗留的和新兴的PFAS研究之前收集的血液样本 减肥干预作为体重、血压和血清差异的前瞻性预测因素 脂类。我们预计，干预前的PFAS将与体重减轻、血压和血清的变化相关 脂类。我们还将评估同时接触12种已测量混合物的预期影响。 全氟辛烷磺酸。最后，我们将探索PFAS和先前测量的血清之间的横截面关联。 干预前血液样本中代谢、血脂、激素和肝功能的生物标志物。 我们将是第一个关于PFAS暴露和儿童体重减轻的调查，也是美国第一个关于PFAS的研究 减肥的重点是西班牙裔年轻人。我们的经验保证了我们项目的圆满完成 他们实施了母公司淡水河谷的研究，并拥有必要的流行病学专业知识， 生物统计学、分析化学和运动生理学。拟议的试点研究是漫长的 促进对包括全氟辛烷磺酸在内的环境因素如何影响体重的理解的长期战略 在儿童中的损失，以制定有针对性的干预措施。这些数据将用于开发R01应用程序 支持更大、更明确、更机械化的未来研究，以解决这一重要的生物医学研究 关于全氟辛烷磺酸对儿童减肥的肥胖效应的差距。

Child obesity is a public health crisis that disproportionately impacts Hispanic children. We propose a pilot study of associations between perfluoroalkyl substances (PFAS) with weight lost among overweight/obese Hispanic children who participated in a 10-week weight loss intervention. The focus will be on pre- vs. post-intervention differences in body weight, blood pressure and serum lipids associated with pre-intervention PFAS exposure. The results will have implications for identifying factors that modify weight loss in children, and will lay the groundwork for a more definitive and larger investigation to be supported by an R01 application. Our proposal addresses a critical research gap. Despite widespread exposure to PFAS among children, experimental evidence of obesogenic effects, and a growing body of epidemiologic results suggesting obesogenic effects, the impact of PFAS exposure on children’s weight loss has yet to be evaluated. Furthermore, no studies have focused on PFAS and weight loss in a Hispanic population, which experiences a greater obesity risk than non-Hispanic children. This proposal builds upon the Vidas Activas y Familias Saludables (VALE) study, a culturally-tailored 10-week community-based weight loss intervention, which significantly reduced children’s BMI, percent body fat, blood pressure and serum non-high density lipoproteins. We will measure 12 legacy and emerging PFAS in VALE study blood specimens previously collected before the weight loss intervention, as prospective predictors of the differences in body weight, blood pressure and serum lipids. We expect that pre-intervention PFAS will correlate to changes in weight loss, blood pressure and serum lipids. We will also estimate the prospective impact of simultaneous co-exposure to the mixture of 12 measured PFAS. Finally, we will explore cross-sectional associations between PFAS and previously measured serum biomarkers of metabolism, lipids, hormones and liver function in pre-intervention blood specimens. Ours will be the first investigation of PFAS exposure and children’s weight loss, and the first US study of PFAS and weight loss focused upon Hispanic youth. Successful completion of our project is ensured by the experience of the team, who implemented the parent VALE study, and have the necessary expertise in epidemiology, biostatistics, analytical chemistry and exercise physiology. The proposed pilot study is the first step in a long term strategy to advance understanding of how exposure to environmental factors, including PFAS, affect weight loss among children, to develop targeted interventions. These data will be used to develop an R01 application to support a larger, more definitive and mechanistic future study to address this important biomedical research gap regarding the obesogenic effects of PFAS on weight loss in children.