UT Gastroenterology/Hepatology Research Training Program

描述(由申请人提供)： 德克萨斯大学胃肠病学/肝脏学研究培训计划 放在消化和肝病科的实验室里 在华盛顿大学几个基础科学系的实验室里 德克萨斯西南医疗中心和达拉斯退伍军人事务医疗 中心校园。在约翰·M·迪奇博士的指导下，斯图尔特·J。 Spechler和Dwain L.Thiele，申请者经过仔细筛选和 采访过了。每个成功的申请者将承担一个重大的研究项目。 在一名或多名成员的直接监督下工作两至四年 高级研究学院。此外，每个实习生将有近 与其他高级研究学院和不同 基础科学系。正在进行的实验室中的项目 这些教职员工非常多样化，涉及各种各样的技术。 在细胞和分子生物学方面。代表性项目包括详细的 对可供选择的生化途径的性质的研究 胆汁酸的生物合成，孤儿核受体在控制中的作用 胆汁酸合成和甾醇转运的研究，分析了治疗胆汁酸的新方法 丙型肝炎，细胞毒性淋巴细胞在肝炎等疾病中的作用 和炎症性肠病以及新描述的胆固醇的作用 胆汁胆固醇分泌中的羟基酶和ABCA1蛋白。最初 所有受训人员都参加了伦理生物学表演的正式讲座。 研究，并在全年定期参加研究会议 以及该部门的临床会议。此外，还有一个为期两年的 生理学、分子生物学和细胞生物学讲座周期 指胃肠道的器官。在这两到四年中 在紧张的研究工作过程中，学员将学会利用各种 分子和细胞生物学常用的基本实验室程序。如果 实习生从事临床研究，一年后参加 在人类研究的各个方面的漫长的正规课程。所有人的进步 定期对受训人员进行监测，在这段紧张时期结束时 在研究方面，每个学员还将有机会完成他/她的研究 临床培训。有关于在医学上使用动物的正式课程 研究和在特殊问题上的伦理人情调查。的确有 招募代表人数不足的少数族裔的积极计划。

DESCRIPTION (provided by applicant): Training in the UT Gastroenterology/Hepatology Research Training Program takes place in the laboratories of the Division of Digestive and Liver Diseases and in the laboratories of several basic science departments at The University of Texas Southwestern Medical Center and the Dallas Veteran's Affairs Medical Center campuses. Under the direction of Drs. John M. Dietschy, Stuart J. Spechler and Dwain L. Thiele, applicants are carefully screened and interviewed. Each successful applicant will undertake a major research project for two to four years under the direct supervision of one or more members of the Senior Research Faculty. In addition, each trainee will have close interactions with other Senior Research Faculty and with members of various basic science departments. The projects that are ongoing in the laboratories of these faculty members are very diverse and involve a wide variety of techniques in cellular and molecular biology. Representative projects include detailed studies into the nature of alternative biochemical pathways for the biosynthesis of bile acids, the role of orphan nuclear receptors in the control of bile acid synthesis and sterol transport, an analysis of new treatments for hepatitis C, the role of cytotoxic lymphocytes in diseases such as hepatitis and inflammatory bowel disease and the role of newly described cholesterol 24 hydroxylase and the ABCA1 protein in biliary cholesterol secretion. Initially all trainees attend formal lectures in the performance of ethical biological research and, throughout the year, participate in regular research conferences and clinical conferences in the division. In addition, there is a two-year cycle of lectures devoted to the physiology, molecular biology and cell biology of the organs of the gastrointestinal tract. Throughout this two to four year course of intense research work, the trainees will learn to utilize a variety of basic laboratory procedures common to molecular and cell biology. If the trainee is engaged in clinical investigation, he/she will participate in a year long formal course in various aspects of human research. The progress of all trainees is monitored on a regular basis and, at the end of this intense period of research, each trainee will also have the opportunity of completing his/her clinical training. There are formal courses in the use of animals in medical research and in the special problems of ethical human investigation. There is an active program for recruiting underrepresented minorities.