HEMOGLOBIN and BLOOD PROTEIN CHEMISTRY

描述（由申请人提供）： 血红蛋白和血液蛋白化学的培训计划为化学家，生物化学家，生物化学家和生物学家提供血红蛋白，血液蛋白和循环蛋白的化学研究培训。培训教师积极参与蛋白质内的电子转移，氧结合血红素蛋白，膜包埋蛋白质的结构，参与调节过程的蛋白质结构，细胞免疫学，转录调节和凝血过程的研究。他们提供超快动力学，X射线晶体学，NMR，蛋白质化学，基因调控，免疫化学和血液蛋白质的调节性翻译后修饰方面的培训。学员有机会通过培训计划的跨学科性质接受广泛的技术培训。该培训计划为加州圣地亚哥大学的跨学科培训提供了一个连续的场所，它连接了主校区部门和医学院。翻译研究培训一直是该计划的长期目标之一 25名培训教师来自不同的课程，包括化学和生物化学（15），生物学（2），物理学（2），医学（2）和药理学（4）。从历史上看，该计划的重点一直是生物物理化学应用于血红素蛋白和血液蛋白，这解释了化学和生物化学系的较大贡献。 六名博士前学员的支持要求将根据他们的研究兴趣和记录的研究进展，从参加部门的研究生课程的研究生的大池选择。申请支持的五名博士后学员将根据他们以前的研究贡献以及他们提出的研究对血红蛋白和血蛋白的相关性从申请加入培训教师研究计划的候选人中选择。 培训是通过实验室研究参与教师的指导下，通过在参与部门的正式讲座课程，通过定期安排部门和小组研讨会，并通过在使用仪器的个人培训。博士前培训的持续时间通常为三年，博士后培训的持续时间通常为两年。

DESCRIPTION (provided by applicant): The training program in Hemoglobin and Blood Protein Chemistry provides training to chemists, biochemists, biophysicists, and biologists in hemoproteins, blood proteins, and circulating proteins concentrating on chemical studies. The training faculty are actively engaged in studies of electron transfer within proteins, oxygen binding to hemoproteins, the structure of membrane-embedded proteins, the structure of proteins involved in regulatory processes, cellular immunology, transcriptional regulation and coagulation processes. They provide training in ultra fast kinetics, X-ray crystallography, NMR, protein chemistry, gene regulation, immunochemistry and regulatory post-translational modifications of blood proteins. The trainees have the opportunity to receive training in a wide array of techniques through the interdisciplinary nature of the training program. The training program has provided a continuous venue for interdisciplinary training at the University of California San Diego that bridges the main campus departments and the School of Medicine. Translational research training has been one of the long-standing goals of the program The twenty-five training faculty are from diverse programs including Chemistry and Biochemistry (15), Biology (2), Physics (2), Medicine (2) and Pharmacology (4). Historically, the emphasis of the program has been the application of biophysical chemistry to hemoproteins and blood proteins, which explains the larger contribution from the Department of Chemistry and Biochemistry. The six predoctoral trainees for which support is requested will be selected on the basis of their research interests and documented progress in research from a large pool of graduate students enrolled in the graduate programs of the participating departments. The five postdoctoral trainees for which support is requested will be selected on the basis of their previous research contributions and relevance of their proposed research to Hemoglobin and Blood Proteins from among candidates who have applied to join the research programs of training faculty. Training is provided through laboratory research under the direction of the participating faculty, through formal lecture courses in the participating departments, through regularly scheduled departmental and small group seminars, and through individual training in the use of instrumentation. The duration of the predoctoral training is typically three years, and the duration of the postdoctoral training is typically two years.