Rural-Urban Differences in Polygenic Associations for Health and Health Behaviors

项目总结 该项目通过研究城乡健康差距的潜在作用，提供了一个不同的视角。 根据心血管健康(CVH)风险的遗传易感性。这项工作的发现提供了关键的 鉴于了解基本和复杂的起源的重要性，对人口健康政策的洞察 健康挑战，无论是社会挑战还是生物挑战，或者两者兼而有之。我们使用了五波来自 全国青少年到成人健康纵向研究(Add Health)，并建立在最近的研究基础上 在四个测量和自我报告的指标中显示出明显的城市心血管健康优势 CVH的病因：1)肥胖；2)高胆固醇；3)高血压；4)糖尿病。我们的研究考察了农村-城市 CVH的每一项指标与其相应的多基因评分之间的相关性差异 (PGS)，衡量每个健康结果的遗传易感性。其中三个的PGS值 健康结果已经存在，我们为高血压创建了PGS估计。将制定这一措施 可用于增加健康用户，以推动对社会和遗传方面的交集的额外研究 健康差距的问题。基于发表的关于城乡差距的少量研究，我们预计 与城市居民相比，农村居民对CVH的遗传影响要低得多 该地区的居民。这样做，这项研究将有助于相关的社会和遗传流行病学的文献。 农村和城市的健康差距。

PROJECT SUMMARY This project offers a different perspective on rural-urban health disparities by examining the potential role played by genetic predisposition toward cardiovascular health (CVH) risk. The findings from this work provide critical insight for population health policy given the importance of understanding the fundamental and complex origins of health challenges, be they social or biological, or a combination of both. We use five waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and build upon recent research that has demonstrated a clear urban cardiovascular health advantage across four measured and self-reported indicators of CVH: 1) Obesity; 2) High Cholesterol; 3) Hypertension; and 4) Diabetes. Our study examines rural-urban differences in the association between each of these measures of CVH and its corresponding polygenic score (PGS) which measures genetic predisposition toward each of the health outcomes. PGS values for three of these health outcomes already exist and we create PGS estimates for hypertension. This measure will be made available to Add Health users to fuel additional research on the intersections between social and genetic aspects of health disparities. Based on the small amount of research published on rural-urban disparities, we anticipate that genetic influences on CVH will be substantially lower among residents of rural areas compared to urban area residents. In doing so, this study will contribute to literatures in both social and genetic epidemiology related to rural-urban health disparities.