Institutional Collaboration Between Liverpool STM & CDC on Malaria

利物浦热带医学院(LSTM)是世界领先的热带医学机构之一。 欧洲；LSTM和CDC旨在加强研究合作，共同开展应用 研究以确定、评估和实施控制疟疾的各种干预措施 在非洲和亚洲的疟疾传播环境，并以一种相辅相成的方式努力实现 减少疟疾(RBM)倡议。 联合研究活动包括1)孕期疟疾研究，包括：a)提供技术援助 支持世卫组织/SEARO和印度疟疾研究理事会(MRC)记录疟疾负担 亚洲的妊娠期(MiP)和b)评估现有和新的抗疟药的安全性和有效性 多种药物联合用于儿童和孕妇疟疾的治疗和预防 通过对现有试验数据的荟萃分析，在非洲和亚洲开展了中心药效试验。2)青年学生的学习 儿童确定有效的初始抗疟疾治疗的作用和每月的额外好处 出院后间歇预防治疗在预防反跳中的作用 撒哈拉以南非洲地区严重的疟疾、贫血和幼儿死亡率；以及3)对 艾滋病毒和疟疾之间的相互作用以a)确定药物与药物之间相互作用的可能性 抗疟药、抗逆转录病毒药物和复方新诺明在中国HIV感染者中的应用 撒哈拉以南非洲，以及b)确定成功控制疟疾对艾滋病毒疾病的影响 撒哈拉以南非洲感染艾滋病毒的成年人的衰退率。 地方协作研究小组的能力发展将是研究的一个重要组成部分 活动，通过对参与合作研究的当地调查人员和卫生官员进行正式培训 以及为所有类别的工作人员提供有关领域的“在职”培训，如良好的临床实践。 作为这些活动的一部分，将于#年设立孕期疟疾研究工作组。 与世卫组织和疾控中心以及其他几个主要研究小组合作，指导研究议程 并加快确定、评估和执行撒哈拉以南地区的初级保健方案控制战略 非洲和亚洲。秘书处的总部将设在LSTM。

The Liverpool School of Tropical Medicine (LSTM) is one of the leading institutions of tropical medicine in Europe; The LSTM and CDC aim to strengthen their research collaboration to jointly conduct applied research to identify, evaluate, and implement interventions for the control of malaria across a range of malaria transmission settings in Africa and Asia and work in a complimentary way towards the targets set by the Roll Back Malaria (RBM) initiative. Joint research activities include 1) studies of malaria in pregnancy including: a) provision of technical support to WHO/SEARO and the Indian Malaria Research Council (MRC) to document the burden of malaria in pregnancy (MiP) in Asia and b) evaluate the safety and efficacy of existing and new antimalarial combinations in the treatment and prevention of malaria in children and pregnant women through multi- centre efficacy trials in Africa and Asia, and by use of meta-analyses of existing trial data. 2) studies in young children to define the role of effective initial antimalarial treatment and the additional benefits of monthly Intermittent Preventive Therapy during the post-discharge period (IPTpd) in the prevention of rebound severe malaria anaemia and mortality in young children in sub-Saharan Africa; and 3) studies of the interaction between HIV and malaria to a) determine the potential for drug-drug interactions between antimalarials, ARVs and cotrimoxazole prophylaxis in HIV-infected non-pregnant and pregnant individuals in sub-Saharan Africa, and b) to determine the impact of successful control of malaria on HIV-disease Drogression rates in HIV-infected adult individuals in sub-Saharan Africa. Capacity development of local collaborative research groups will be an important component of research activities, through formal training of local investigators and health officials involved in collaborative research and 'on-the-job' training for all categories of staff in relevant areas such as good clinical practice. As part of these activities a Malaria in Pregnancy (MiP) research working group will be established in collaboration with WHO and CDC and several other leading research groups to guide the research agenda and expedite the identification, evaluation and implementation of MiP control strategies in sub-Saharan Africa and Asia. The secretariat will be based at the LSTM.