Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

摘要/摘要 在这份SBIR赠款提案中，“超低失真和噪声电子设备实现了临床MPI成像平台，” 我们将为临床磁粉成像(MPI)平台开发射频子系统，以支持三类 MPI应用的一部分：细胞跟踪、功能成像和内源性对比成像。我们的总体方法是 为了通过最小化失真、增加发送/接收通道、去耦合 改进前置放大器，开发新的脉冲序列。 MPI是一种新兴的分子和示踪剂成像技术，可以直接检测磁性纳米颗粒 (MNPs)，在毫米级分辨率下具有高灵敏度。MPI图像是示踪剂分布的直接视图，不需要 来自组织的信号，不受空气等材料的干扰，图像强度与 示踪剂浓度。这种“热点”的对比提供了没有歧义的空间定位和量化。 MPI的对比度类似于核医学，但没有工作流程、安全性和半衰期限制 放射性示踪剂。MPI在大脑和身体中有许多应用，正如我们的小客户所展示的那样 动物。尽管多个机构做出了重大努力，但临床MPI扫描仪的缺乏仍然是一个重要问题 这项技术的局限性。 在这个直接到第二阶段SBIR的提案中，我们将通过建立世界上 第一台通用临床MPI扫描仪，可为客户在我们的 临床前仪器。我们将设计和实现一个新的发送/接收子系统，并将其安装在我们的 样机扫描仪可实现临床成像应用所需的性能。这是一项新的 发送/接收子系统包括以下创新，将我们的敏感度从目前的粗糙 通过以下具体目标使原型接近物理极限： 目标1.将传输失真和噪声底限驱动到单通道Tx/Rx线圈的物理极限 目的2.设计一种临床多通道收发子系统 目标3.开发新的捕获脉冲序列以提高灵敏度、分辨率和速度

SUMMARY/ABSTRACT In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogenous contrast imaging. Our overall approach is to improve sensitivity and resolution by minimizing distortion, adding transmit/receive channels, decoupling, improving preamplifiers, and developing new pulse sequences. MPI is an emerging molecular and tracer imaging technology that directly detects magnetic nanoparticles (MNPs) with high sensitivity at mm-scale resolutions. MPI images are direct views of tracer distribution with no signal arising from tissue, no perturbations from materials such as air, and image intensity directly linear with tracer concentration. This “hot-spot” contrast provides spatial localization and quantification without ambiguity. MPI’s contrast is similar to nuclear medicine but without the workflow, safety, and half-life limitations of a radioactive tracer. MPI has many applications in the brain and body, as demonstrated by our customers in small animals. Despite significant efforts by multiple institutions, the lack of a clinical MPI scanner remains a significant limitation for the technique. In this Direct to Phase II SBIR proposal, we will advance the medical imaging field by building the world’s first general-purpose clinical MPI scanner to serve the myriad applications our customers are testing on our preclinical instrument. We will design and implement a new transmit/receive subsystem and install it in our prototype scanner to achieve the performance necessary for clinical imaging applications. This new transmit/receive subsystem includes the following innovations that push our sensitivity from our current rough prototype to near the physics limit through the following specific aims: Aim 1. Drive transmit distortion and the noise floor to the physics limit for a one-channel Tx/Rx coil Aim 2. Design a clinical multi-channel transmit and receive subsystem Aim 3. Develop new acquisition pulse sequences to improve sensitivity, resolution, and speed