1/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center

总结-总体组成部分 佛罗里达州-加利福尼亚州癌症研究，教育和参与（CaRE 2）健康公平是由 佛罗里达大学（UF）、佛罗里达农工大学（FAMU）和南加州大学诺里斯分校 综合癌症中心（USC-NCCC），以消除佛罗里达，加州和 全国范围内。CARE 2中心的长期目标是减少黑人和拉丁美洲人的癌症差异， 培训和增加代表性不足的黑人和拉丁裔科学家进行健康差异研究， 增加在FAMU的研究能力，并增加在UF和USC-NCCC癌症差异研究。的 双海岸的位置提供了独特的黑人和拉丁美洲人的多样化人口，促进在一个 前所未有的方式，研究这些令人难以置信的异质人群中的癌症差异。具体地说， 该中心将重点研究相关问题并满足以下需求：（1）黑人亚群，包括 美国出生的，非洲出生的和加勒比出生的黑人;和（2）拉丁美洲亚群，包括墨西哥- 美国人，加勒比海拉丁美洲人，中美洲和南美洲人。这三位一体汇集了调查人员， 美国两个州的医疗机构目前癌症发病率和死亡率最高。主要的科学 该中心的重点是异质少数民族人口之间的翻译差异研究，重点是 以高死亡率著称的癌症。我们建议将专业知识、基础设施和资源共享结合起来， 支持6个创新的转化研究项目，重点是了解生物学基础， 黑人和拉丁裔人口的差异，捕捉这两个群体内的广泛异质性， 重点关注胰腺癌的基础项目（一个完整项目，一个试点项目）和一个重点关注前列腺的完整项目 癌症（目标1）。在研究教育核心的领导下，我们建议培训100名黑人和拉丁美洲人， 研究人员，包括学生和早期研究人员（ESI），在转化癌症健康差异 研究（目标2）。将利用外联核心中现有的社区伙伴关系传播调查结果 在黑人和拉丁裔社区，教育胰腺癌和前列腺癌，并提高参与 生物医学研究（目标3）。最后，规划和评价核心将实施系统规划， 利用创新战略提高中心效率的评估计划（目标4）。所有的研究项目将 通过组织建模核心和生物信息学提供的资源和方法促进和丰富， 统计和方法核心。CARE 2中心的所有活动都将由 行政核心。FAMU-UF-USC伙伴关系非常适合实现这些目标。UF和FAMU 在过去的4年里，我们密切合作，解决佛罗里达黑人的癌症差异。USC-NCCC 提供癌症差异研究的互补和协同专业知识，为拉丁美洲人提供研究培训 人口，并在开发文化敏感的工具，以减少拉丁美洲人之间的癌症差距的专业知识。

SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer health disparities in Florida, California and nationally. The long term goals of the CaRE2 center are to reduce cancer disparities in Blacks and Latinos, to train and increase the pool of underrepresented Black and Latino scientists conducting health disparity research, to increase research capacity at FAMU, and to increase cancer disparity research at UF and USC-NCCC. The bi-coastal location offers access to uniquely diverse populations of Blacks and Latinos, facilitating in an unprecedented way, the study of cancer disparities in these incredibly heterogeneous populations. Specifically, the center will focus on studying relevant issues and serving the needs of: (1) Black subpopulations, including American-born, African-born and Caribbean-born Blacks; and (2) Latino subpopulations including Mexican- Americans, Caribbean Latinos, Central and South Americans. This triad brings together investigators and institutions in the two US states that currently have the highest cancer incidence and mortality. The main scientific focus of the center is translational disparities research among heterogeneous minority populations focusing on cancers known for high mortality. We propose to coalesce expertise, infrastructure and share resources in support of 6 innovative translational research projects focused on understanding the biological basis of disparities in Black and Latino populations, capturing the wide heterogeneity within these two groups, with two foundational projects focusing on pancreas cancer (one full, one pilot) and one full project focusing on prostate cancer (Aim 1). Under the leadership of the Research Education Core, we propose to train 100 Black and Latino investigators, including students and early stage investigators (ESI), in translational cancer health disparity research (Aim 2). Existing community partnerships in the Outreach Core will be leveraged to disseminate findings in the Black and Latino community, educate about pancreas and prostate cancer, and improve participation in biomedical research (Aim 3). Finally, the Planning and Evaluation Core will implement a systematic planning and evaluation plan to improve Center effectiveness using innovative strategies (Aim 4). All research projects will be facilitated and enriched by resources and approaches provided by the Tissue Modeling Core and Bioinformatics, Statistical and Methodological Core. All CaRE2 Center’s activities will be centralized and overseen by the Administrative Core. The FAMU-UF-USC partnership is ideally suited to achieve these aims. Both UF and FAMU have worked closely together addressing cancer disparities in Florida Blacks for the last 4 years. USC-NCCC provides complementary and synergistic expertise in cancer disparities research, research training for the Latino population, and expertise in developing culturally-sensitive tools to reduce cancer disparities among Latinos.