Technology Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)

摘要-技术核心 艾滋病毒/艾滋病护理点技术创新中心的技术核心和新兴技术 传染病在西北（C-THAN）将支持重要的POC和家庭为基础的发展 专门用于诊断和管理艾滋病毒/艾滋病、相关病症和新出现的 在低收入和中等收入国家，特别是撒哈拉以南非洲，我们将支持 专门为医疗基础设施薄弱或有限的低资源环境设计的技术项目 例如用电、制冷和/或中央供水受到限制。成功的测试将是：用户- 友好，只需要在其操作和维护的本地培训;可在低成本低成本制造 耗材;快速结果;耐用;包含设备/测定性能的内部检查，自校准， 错误诊断。C-THAN支持的项目将符合艾滋病毒/艾滋病研究的高优先主题，或 应对新出现或重新出现的疾病，适应低资源环境的条件， 在发展中国家商业化的可能性很大。C-THAN的一个独特之处是我们的 承诺通过提供具体的资助机会，促进中低收入国家的本地技术发展， 通过协调一致的努力，专门为中低收入国家的艾滋病毒护理培育POC技术。 这一目标得到了我们成熟和新兴的非洲生物医学工程接入网络的支持 通过我们在尼日利亚、坦桑尼亚、马里、塞内加尔和南非的合作伙伴，我们将建立一个强大的 通过确定诊断需求，招募符合以下要求的项目， 这些需求，监测资助项目的进展情况，提供服务和指导， 项目成熟，并促进技术转移到临床验证。则输出将为 具有高度临床影响力的产品管道，由来自以下领域的均衡研究组合开发而成： C-THAN技术核心

SUMMARY – TECHNOLOGY (TECH) CORE The Technology Core of The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern (C-THAN) will support the development of vital POC and home-based technology specifically designed for diagnosis and management of HIV/AIDS, related conditions, and emerging infectious diseases in low- and middle-income countries with emphasis on sub-Saharan Africa. We will support technology projects specifically designed for low resource settings with low or limited medical infrastructure such as restricted access to electricity, refrigeration and/or central water supply. A successful test will be: user- friendly, requiring only local training in its operation and maintenance; manufacturable at low cost with low cost consumables; rapid result; durable; and contain internal checks of device/assay performance, self-calibration, and error diagnosis. Projects supported by C-THAN will conform to high priority topics of HIV/AIDS research or address emerging or re-emerging diseases, be amenable to the conditions of low resource environments, and have high likelihood of commercialization in developing countries. A unique feature of C-THAN is our commitment to fostering local technology development in LMICs by providing specific funding opportunities for home-grown solutions via coordinated efforts to specifically incubate POC technology for HIV care in LMICs. This goal is supported by our access network of well established and emerging African biomedical engineering programs through our partners in Nigeria, Tanzania, Mali, Senegal, and South Africa. We will build a robust pipeline of POC and home-based technology by identifying diagnostic needs, recruiting projects that meet those needs, monitoring progress made in funded projects, providing services and mentorship to guide projects to maturity, and facilitating the transfer of technologies to clinical validation. The output will be a pipeline of products of high clinical impact developed from a well-balanced research portfolio originating from the C-THAN Technology Core.