Databases and Data Models Enabling Neuroinformatics

描述(由申请人提供)：神经科学包括广泛的假设、探索、技术和模型；神经科学家是一个多元化的群体，在许多学科都有基础。神经科学数据的范围和范围比以往任何时候都更加复杂，以数字方式获取和分析数据的实验室数量持续增加。因此，神经科学家对能够交换数据的需求是巨大的，而且还在不断增长。 该项目将加强和扩大侧重于神经生理学的数据库，以及跨越当代脑科学和信息科学的数据交换和互操作性标准。三个开放的可访问的Web资源将支持神经生理学数据的共享，并提供人脑项目(HBP)互操作性的技术：Neurodata ase.org、brainml.org和data haring.net。这个正在进行的项目的五个相互关联的目标融合了神经科学和信息学，以开发具有规划意义的HBP领域，包括：“数据库、图形界面、查询方法、信息检索、数据可视化和操纵，以及通过开发综合分析工具、合成和电子协作工具进行数据集成。”AIMS I和II增强和扩展了NationalDataase.org及其用户友好的多平台查询、查看器、元数据和数据输入工具，以帮助对来自其他哺乳动物大脑区域和制剂以及来自转基因模型系统的数据进行数据交换和重新分析，从而将神经信息学与生物信息元数据联系起来。 在互操作性方面，AIMS三和四将加强和扩展BrainML，这是该项目设计的一种可扩展的标准化数据描述语言，用作神经科学数据库之间以及数据库与其用户之间的接口。在完成了对神经生理学和皮质数据的BrainMetaL抽象和BrainML多层语言定义，并展示了与同行资源的链接之后，该项目将整合项目设计的和兼容的社区衍生扩展，以支持广泛的神经生物学技术和准备。 第五个目标是利用这项工作开发、提供和支持两种资源，使神经信息学开发人员能够为神经科学的其他领域提供互补的、可互操作的数据共享。神经数据库构建工具包将帮助其他神经科学社区更快地设计和实施神经数据库。BrainML-X将使HBP小组能够构建接口、查询服务器和分发者，以及中介来实现神经信息资源之间的互操作性

DESCRIPTION (provided by applicant): Neuroscience encompasses a broad range of hypotheses, explorations, technologies, and models; neuroscientists are a diverse group with grounding in many disciplines. The scope and range of neuroscience data is ever more complex, and the number of laboratories acquiring and analyzing data digitally continues to increase. As a result, the need for neuroscientists to be able to exchange data is significant and growing. The project will enhance and expand databases focused on neurophysiology, as well as standards for data exchange and interoperability that span contemporary brain and informational sciences. Three open accessible Web resources will support sharing of neurophysiology data and present techniques for Human Brain Project (HBP) interoperability: neurodatabase.org, brainml.org, and datasharing.net. The five linked Aims of this ongoing project fuse neuroscience and informatics to develop HBP areas of programmatic interest including: "databases, graphical interfaces, querying approaches, information retrieval, data visualization and manipulation, and data integration through the development of integrated analytical tools, synthesis, and tools for electronic collaboration." Aims I and II enhance and expand neurodatabase.org and its user-friendly multiplatform query, viewer, metadata, and data entry tools to aid data exchange and reanalysis for data from additional mammalian brain regions and preparations, and from genetically-altered model systems, linking neuroinformatic with bioinformatic metadata. Towards interoperability, Aims III and IV will enhance and expand BrainML, the extensible standardized data description language designed by the project to serve as an interface among neuroscience databases and between databases and their users. After completing BrainMetaL abstractions and BrainML multilayered language definitions for neurophysiology and cortical data, and demonstrating links to peer resources, the project will integrate project-designed and compatible community-derived extensions supporting a wide range of neurobiological techniques and preparations. The fifth Aim leverages this work to develop, offer and support two resources to enable neuroinformatics developers to provide complementary, interoperable data sharing for other areas of neuroscience. The Neurodatabase Construction Kit will aid other neuroscience communities to more rapidly design and implement neurodatabases. BrainML-X will enable HBP groups to build interfaces, query servers and distributors, and mediators to implement interoperability among neuroinformatic resources