Mesenchymal Progenitor cells and intervertebral disc repair

腰痛影响80%的普通人群，是一个主要的社会和经济负担，因此显然需要有效的治疗。2006年，美国每年用于治疗腰痛的直接和间接费用超过1000亿美元。我们将在再生策略中使用骨髓衍生的多能祖细胞在绵羊机械不稳定模型中进行椎间盘修复，该模型再现了与人类相似的早期退行性变化。

Low back pain affects 80% of the general population and is a major social and economic burden thus there is a clear need for effective treatment. Annual direct and indirect costs for low back pain exceeded $100 billion in the USA in 2006. We will use bone marrow derived multipotent progenitor cells in a regenerative strategy to undertake repair of the intervertebral disc in an ovine mechanical destabilisation model which reproduces early degenerative changes similar to those evident in man.