Cancer Center Support Grant

项目摘要 自2012年癌症中心支持补助金（CCSG）的最后一次竞争性审查以来， Perlmutter癌症中心（PCC），以前是纽约大学癌症研究所，已经经受住了 超级风暴桑迪，并出现了一个深刻的转变和扩张时期。由一个 来自劳里和艾萨克·珀尔马特的变革性礼物，来自纽约大学的更新和增强的机构支持 Langone卫生系统（NYULH）和新的主任，我们已经彻底改革了我们的领导团队，扩大了我们的 临床和研究设施，并制定了一个新的战略愿景，并开始实施一个新的战略 计划在该计划的指导下，我们的科学计划和共享资源进行了重组， 开始了一场大规模的招聘活动，又产生了12名新的领导和/或高级教师 新成员，其他15名新的癌症中心教职员工，以及68名新成员。修订后，更多 根据严格的标准，成员已精简到180个正式成员和56个联系成员。成员 开展研究作为5个科学计划的一部分，癌症基因组动力学，癌细胞生物学，肿瘤 免疫学，黑色素瘤，或流行病学和癌症控制，由10个共享资源和2 开发共享资源。我们的临床试验办公室已经重组并大幅扩大 在新的领导下，一个新的第一阶段单位已经开放。随后，审判的可用性、质量和应计费用 增加了，而开审所需的时间则明显缩短。随着我们的增长 我们已重新界定及扩大服务范围。援建 在纽约大学朗格尼医学院和纽约大学医学院设立新的人口健康系， 在纽约大学主校区的全球公共卫生，我们的人口科学研究的广度有所增加 和质量最重要的是，我们的实验室科学家已经做出了范式转变的发现，我们的临床医生 已经领导了多项改变实践的试验，我们的人口科学家已经对 癌症的原因和如何控制这种疾病，促成了重大的公共卫生政策的变化， 倡议，并建立了新的社区外展计划，以解决特定的癌症负担， 我们流域的健康差距。虽然PCC位于一个城市，与其他四个NCI指定 癌症中心，我们的集水区与其他人有很大的不同：我们是降低癌症的主要提供者。 曼哈顿，并已扩展到布鲁克林，最大和发展最快的行政区在纽约市， 以及皇后区和长岛

Project Summary Since the last competitive review of this Cancer Center Support Grant (CCSG) in 2012, the NCI-designated Perlmutter Cancer Center (PCC), previously NYU Cancer Institute, has weathered the devastation of Superstorm Sandy and emerged into a period of profound transformation and expansion. Propelled by a transformative gift from Laurie and Isaac Perlmutter, renewed and enhanced institutional support from the NYU Langone Health system (NYULH) and a new Director, we have overhauled our leadership team, expanded our clinical and research facilities, and developed a new strategic vision and began implementing a new Strategic Plan. Guided by this plan, our Scientific Programs and Shared Resources have been restructured, and we embarked on a major recruitment campaign that has yielded 12 additional new leadership and/or senior faculty recruits, 15 other new cancer center faculty recruits, and 68 new members overall. Under revised, more stringent criteria, membership has been streamlined to 180 full members and 56 associate members. Members carry out research as part of 5 Scientific Programs, Cancer Genome Dynamics, Cancer Cell Biology, Tumor Immunology, Melanoma, or Epidemiology and Cancer Control, assisted by 10 Shared Resources and 2 Developing Shared Resources. Our clinical trials office has been reorganized and substantially expanded under new leadership and a new Phase I unit has opened. Subsequently, trial availability, quality, and accrual have increased, while the time to trial opening has been markedly reduced. In line with our increased geographic scope and patient population, we have redefined and enlarged our catchment area. Aided by the creation of a new Department of Population Health at NYU Langone School of Medicine and the College of Global Public Health at the NYU main campus, our Population Sciences research has increased in breadth and quality. Most importantly, our laboratory scientists have made paradigm-shifting discoveries, our clinicians have led multiple practice-changing trials, and our population scientists have yielded new insights into the causes of cancer and how to control the disease, contributed to major public health policy changes and initiatives, and established new community outreach programs that address the specific cancer burdens and health disparities in our catchment area. Although PCC is located in a city with four other NCI-designated cancer centers, our catchment area differs substantially from the others: we are the major provider to lower Manhattan, and have expanded into Brooklyn, the largest and fastest growing borough in New York City, as well as to Queens and Long Island.