University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

抽象的。临床和转化科学(CTS)正处于重大技术进步的十字路口，需要 学术界与社区的伙伴关系建立在信任的基础上，以便有效和迅速地部署最佳做法。UMN CTSA Hub将以经过验证的承诺为基础，加快有效的CTS。AIM 1将提供新颖的 通过新的临床办公室减少研究障碍并加速转化为实践的基础设施 研究和社区事务，以增强CTSI的能力，以应对和促进强大的 可持续的社区关系超越单一调查员项目。AIM 2将提供高质量 通过临床研究支持中心(85名员工)提供高效的研究服务和资源， 试验障碍和支持研究设计、生物统计学、生物信息学、法规遵从性、 合同和更多。加快多样性、公平和包容性进程将促进与我们的 多样化的人口。学习卫生系统(LHS)和持续质量改进计划将加快实施 实施新的增强功能。目标3将培养和培训一支强大、多样化的CTS员工队伍， 新工具和计划；开发和测试新的试验流程和参与者满意度；然后传播 并在地方和全国范围内实施学习。量身定制的增强功能将使CTS培训个性化 社区、学术和劳动力专业人员，注意多样性，对非 会说英语的人，调查员入门读物，研究职业发展系列等等。CTSI的农村健康 该计划提供公平的博士后奖学金和为期一年的卫生政策和社区领导人培训 领导力。文化能力培训将促进与我们的多元文化社区的接触。训练有素 社区卫生工作者将推动研究传播到实践和社区。目标4 将培养领导力、团队科学和数据共享，以支持包括领导力计划在内的合作， 专业教练，垂直整合的务虚会，团队功能研讨会，北方领导力 适用于初级教员的创新团队科学计划和获得CTSI领导技能的激励措施。 Health Informatics将支持高级数据管理、分析基础设施以及电子健康 Record&LHS信息系统。目标5通过部署以下方式努力实现健康公平和反对结构性种族主义 为广大社区培训CHW和中心合作伙伴的公平框架和反种族主义研究实践 投入和决策。建立全国人口水平可量化指标地理数据库。 文化和经济变量使用一种新的多维措施将系统性种族主义门户联系起来 健康和临床数据，定义结构性种族主义对研究登记和数据收集的国家影响 产前暴露甲基苯丙胺后儿童早期认知功能验证项目。冲击力。 凭借新颖的基础设施、多元化的下一代领导者和训练有素的多元化员工队伍，我们的中心 和区域社区将共同开发和实施CTS进步，以改善健康。

Abstract. Clinical and translational science (CTS) is at the crossroads of major technology advances requiring academia-community partnerships anchored on trust for effective & rapid deployment of best practices. UMN CTSA Hub will build on proven commitments to accelerate impactful CTS. Aim 1 will provide novel infrastructure to reduce research barriers and accelerate translation to practice via a new Office of Clinical Research and Community Affairs to augment CTSI’s capacity to respond to and facilitate robust and sustainable community relationships transcending single investigator projects. Aim 2 will deliver high quality and efficient research services and resources via Clinical Research Support Center (85 staff) that will lessen trial barriers and support all aspects of study design, biostatistics, bioinformatics, regulatory compliance, contracts and more. Accelerating diversity, equity and inclusion progress will facilitate connectivity to our diverse population. A learning health system (LHS) and continuous quality improvement program will expedite implementation of novel enhancements. Aim 3 will cultivate and train a strong, diverse CTS workforce with new tools and programs; develop and test novel trial processes and participant satisfaction; then disseminate and implement learnings locally and nationally. Tailored enhancements will personalize CTS training for community, academic and workforce professionals, with attention to diversity, informed consent for non- English speakers, an investigator primer, research career development series and more. CTSI’s Rural Health Program offers an Equity Postdoctoral Fellowship and year-long community leader training in health policy & leadership. Cultural competency training will facilitate engagement with our multicultural community. Trained community health workers (CHWs) will advance research dissemination into practice and community. Aim 4 will foster leadership, team science and data sharing to support collaborations including leadership programs, professional coaching, vertically integrated retreats, team function seminars, Northern Leadership for Innovative Team Science program adapted for junior faculty and incentives to gain CTSI leadership skills. Health Informatics will support advanced data management, analytic infrastructures plus electronic health record & LHS information systems. Aim 5 strives for health equity and against structural racism by deploying an Equity Framework and antiracist research practices to train CHWs and Hub Partners for broad community input and decision-making. We will build a national population level geo-database of quantifiable measures of cultural and economic variables using a novel Multidimentional Measures of Systemic Racism Portal to link health and clinical data, define national impact of structural racism on study enrollment and data collection with a validation project on early childhood cognitive function after prenatal methamphetamine exposure. Impact. With a novel infrastructure, a diverse next generation of leaders and a well-trained diverse workforce, our Hub and regional community will co-develop and implement CTS advancements to improve health.