Training Grant in Precision Cancer Control

项目总结 在美国，超过40%的新癌症病例可以归因于可改变的因素。然而， 尽管关于与癌症风险相关的多水平因素的知识取得了进展，但每年的 预计癌症病例将增加近50%，从2015年的150万新病例增加到约230万 到2050年将达到100万。因此，更多地强调降低癌症风险和癌症控制-以及高度 这一领域需要训练有素的劳动力--以应对预计的增长。精度方面的最新进展 医学已经为潜在的治疗选择带来了巨大的乐观，并可能为如何 发展癌症控制领域。为了充分发挥癌症精准控制的潜力，必须 不仅要评估生物属性，还要考虑行为、生活方式和 环境因素。因此，精确的癌症控制研究需要多学科的方法 实现无缝集成和协作，让我们了解如何识别这些人 谁处于高风险或谁可能受益于具体、有效和可实施的干预措施。因此， 有必要让下一代癌症控制科学家具备以下技能：(1) 准确描述癌症风险增加或预后不佳的人群；(2)确定多层次 导致风险升高或负面结果的因素；以及(3)制定和实施适当的 有效解决这些因素的干预措施。申请新的T32博士后培训计划 福克斯·蔡斯癌症中心旨在为博士后和医学博士后研究员进行创新 针对不同人群的癌症精准控制研究。跨学科培训包括 教学活动的补充计划和密集的指导研究经验，这将装备 受训人员将领导精准癌症控制的独立职业生涯。该计划的教职员工包括25名导师，全部 它们已经建立了获得同行审查资金的记录。我们建议招收2名博士后 每年(为期两年)超过五年奖的研究员。所有研究员都将接受严格的 癌症精确控制的原则，研究设计和方法，拨款，负责任的行为 研究和职业/专业技能发展。T32导师来自广泛的卓越基础 癌症中心的教师拥有广泛的专业知识，从分子生物学，遗传学，流行病学， 生物统计学、地理空间技术、心理学、公共卫生和实施学。丰富的资源 福克斯·蔡斯癌症中心(Fccc)提供的内容包括全面的基因组、生物学、社会文化 行为和环境级别的数据与高级地理空间和统计工具相结合，将支持 我们的教师和他们的实习生将精确的癌症控制方法应用于减少癌症的战略努力 不同人群的风险和死亡率。

PROJECT SUMMARY In the United States, more than 40 percent of new cancer cases can be attributed to modifiable factors. Yet, despite advances in knowledge regarding the multilevel factors associated with cancer risk, the annual number of cancer cases is predicted to increase nearly 50%, from 1.5 million new cases in 2015 to approximately 2.3 million in 2050. Thus, a greater emphasis on cancer risk reduction and cancer control – along with a highly trained workforce in this domain -- is needed to counter this projected increase. Recent advances in precision medicine have resulted in great optimism for potential therapeutic options and may provide a ‘model’ for how to evolve the field of cancer control. To realize the full potential of precision cancer control, it will be imperative to not only assess biologic properties, but to also consider individual variabilities in behavioral, lifestyle, and environmental factors. As a result, precision cancer control research requires multidisciplinary approaches that enable seamless integration and collaboration to inform our understanding of how to identify those individuals who are at elevated risk or who might benefit from specific, effective, and implementable interventions. Thus, there is a significant need to equip the next generation of cancer control scientists with skills required to: (1) precisely characterize the populations at increased risk for cancer or poor outcomes; (2) identify the multilevel factors contributing to elevated risk or negative outcomes; and (3) develop and implement appropriate interventions to effectively address those factors. This application for a new T32 postdoctoral training program at Fox Chase Cancer Center is designed to prepare PhD and MD postdoctoral fellows to conduct innovative research in precision cancer control with diverse populations. The transdisciplinary training includes a complementary program of didactic activities and intensive mentored research experiences, which will equip trainees to lead independent careers in precision cancer control. The Program Faculty include 25 mentors, all of whom have established track records of obtaining peer-reviewed funding. We propose to enroll 2 postdoctoral fellows each year (for two-year terms) over the five-year award. All fellows will receive rigorous training in the principles of precision cancer control, research design and methodology, grant-writing, responsible conduct of research, and career/professional skills development. T32 mentors are drawn from a broad base of exceptional Cancer Center faculty with a breadth of expertise ranging from molecular biology, genetics, epidemiology, biostatistics, geospatial technology, psychology, public health, and implementation science. The rich resources available at Fox Chase Cancer Center (FCCC) include comprehensive genomic, biologic, sociocultural, behavioral, and environmental-level data combined with advanced geospatial and statistical tools that will enable our faculty and their trainees to apply precision cancer control methods in strategic efforts toward reducing cancer risk and mortality across diverse populations.