Research Network to Accelerate Mechanistic Studies of Music for Dementia (RN-MusD)

摘要 阿尔茨海默病和阿尔茨海默病相关性痴呆（AD/ADRD）是最常见的 成年人痴呆症（认知能力下降，导致独立功能丧失）的原因。 大约九分之一的65岁及以上的美国人（11%）患有AD痴呆症， 大约650万人;如果包括相关痴呆症，患病率会增加。有 目前还没有预防或阻止痴呆症进展的治疗方法，尽管FDA批准的6种药物 药物可以帮助缓解症状。患有AD/ADRD的患者会丧失独立性、残疾， 健康和福祉差（发病率），死亡率增加。老年痴呆症患者的护理需求 （PLWD）是复杂的。提供护理的成本很高，护理人员负担很重。那里 不同种族/族裔背景的艾滋病毒/艾滋病感染者在健康方面也存在相当大的差异。因此， 迫切需要确定新颖的、可获得的、文化上相关的和具有成本效益的方法， 减轻这些常见神经退行性疾病的老年人的负担并改善其生活质量 无法治愈我们已经知道超过35年，患有AD的人可以有意义地参与 音乐，甚至到了后期。越来越多的研究得出结论， 音乐治疗或基于音乐的干预（MBIs）体验生活质量的改善， 幸福以及减少行为问题，焦虑和抑郁。尽管有这些令人鼓舞的发现， 研究数量少，许多研究质量低，样本缺乏多样性， 还没有被很好地理解。此外，人们对MBIs对患有糖尿病的人的潜在益处知之甚少。 相关性痴呆（ADRD）使用NIH阶段模型和行为改变科学方法的研究可以 帮助提高研究质量，并提供一个框架，为开发和测试MBIs的背景下， AD/ADRD。此外，使用新型移动的体脑成像（MoBI）技术可以帮助阐明 MBI在现实世界中影响大脑（包括神经调节）和身体的各种功能。到 加速对MBIs影响成年人健康和福祉的机制进行严格的研究 通过AD/ADRD，我们将建立多学科研究网络，以加速对 痴呆症音乐（RN-MusD）网络，代表来自认知神经科学，音乐 治疗，生物医学和神经工程，老年医学和统计学将在 加州圣弗朗西斯科大学、休斯顿大学和亚利桑那州立大学。该网络将 加速AD/ADRD背景下MBI的严格、多学科和机制研究， 实现以下目标：（1）建立一个合作网络，将随着时间的推移而增长;（2）促进 通过试点项目计划进行多学科合作，利用MoBI和研究指导，以及 (3)传播我们网络产生的资源，以维持影响。

ABSTRACT Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) represent the most common causes of dementia (cognition decline that leads to a loss of independent function) among adults. Approximately 1 in 9 Americans age 65 and over (11%) lives with dementia from AD, representing approximately 6.5 million people; prevalence rates increase when including related dementias. There are currently no treatments that prevent or halt the progression of dementia, although the 6 FDA-approved medications can help slow symptoms. Living with AD/ADRD is associated with loss of independence, disability, poor health and well-being (morbidity), and increased mortality. The care needs for people living with dementia (PLWD) are complex. Providing care is associated with high costs and considerable caregiver burden. There are also considerable health disparities for PLWD from diverse racial/ethnic backgrounds. Thus, there is an immediate need to identify novel, accessible, culturally relevant, and cost-effective approaches to reduce the burden and improve quality of life for older adults living with these common neurodegenerative diseases without a cure. We have known for over 35 years that people living with AD can meaningfully engage with music, even into the late stages. An increasing number of studies conclude that PLWD who participate in music therapy or music-based interventions (MBIs) experience improvements in quality of life, and emotional well-being as well as decreases in behavior issues, anxiety, and depression. Despite these promising findings, the number of studies is small, many are low quality, samples lack diversity, and the underlying mechanisms are not yet well understood. In addition, little is known about potential benefits of MBIs for people living with related dementias (ADRD). Studies using the NIH Stage Model and Science of Behavior Change methods can help improve study quality and provide a framework for developing and testing MBIs in the context of AD/ADRD. Moreover, use of novel mobile body-brain imaging (MoBI) technologies could help elucidate how MBIs affect various functions of the brain (including neuromodulation) and body in real-world settings. To accelerate rigorous research about the mechanisms by which MBIs impact health and well-being for adults with AD/ADRD, we will create the multi-disciplinary Research Network to Accelerate Mechanistic Studies of Music for Dementia (RN-MusD). The Network, representing experts from cognitive neuroscience, music therapy, biomedical and neural engineering, geriatrics, and statistics will create three core nodes at the University of California San Francisco, University of Houston, and Arizona State University. The Network will accelerate rigorous, multi-disciplinary, and mechanistic studies of MBIs in the context of AD/ADRD by accomplishing the following aims: (1) build a collaborative Network that will grow over time; (2) promote multidisciplinary collaborations through a pilot project program, leveraging MoBI and research mentoring, and (3) disseminate resources generated by our Network to sustain impact.