Center for Novel Biomarkers of Response

描述（由申请人提供） 行政核心的职能是促进中心的整体组织结构和行政活动，与NIH/NIEHS工作人员的接口，促进研究项目和核心之间的合作，鼓励项目科学家的批评和建议，促进财政责任，并提供灵活的行政结构，以确保整个中心的持续卓越及其实现里程碑的能力。U 54中心的管理由行政核心提供，包括中心主任，两名副主任，他们在管理学术界，工业界和国家实验室的跨学科研究项目方面有经验;一名在转录组学和蛋白质组学分析方面有经验的首席统计学家;内部指导小组，由主任、协理主任、额外的研究项目和核心领导人和两个杰出的科学顾问。每个研究项目和核心由具有完成U 54申请中规定的所有里程碑的专业知识的工作人员组成，各自的领导负责与内部指导团队协调进行实验设计，规划和实施。行政核心还将为所有研究项目和核心提供统计支持，以协助数据分析，传感器平台测试和验证。此外，行政核心将负责：（a）规划和协调U 54中心内的研究活动;（B）促进跨学科和跨组织的互动;（c）协调实验数据的统计分析;（d）确保与NIEHS和暴露生物学研究项目的有效联络;（d）确保有效的财政和资源管理和规划;（e）编写方案中心的文件和报告，并提供旅行和会议安排，以及（g）促进技术转让规划。

DESCRIPTION (provided by applicant) The function of the Administrative Core is to facilitate the overall organizational structure and administrative activities of the Center, interface with NIH/NIEHS staff, foster cooperation between Research Projects and Cores, encourage criticism and advice from the program's scientists, promote fiscal responsibility, and provide a flexible administrative structure to assure the continued excellence of the overall Center and its ability to meet milestones. The management of this U54 Center, provided by the Administrative Core, includes the Center Director, two Associate Directors with experience at managing interdisciplinary research programs in academia, industry and national laboratory; a lead statisticians experienced with transcriptomics and proteomics analysis; an Internal Steering Team made up of the Director, Associate Directors, additional Research Project and Core Leaders and two pre-eminent scientific advisors. Each Research Project and Core consists of staff with the expertise to accomplish all of the milestones set forth in this U54 application with the respective leaders responsible for the experimental design, planning and implementation in coordination with the Internal Steering Team. The Administrative Core will also provide statistical support for all Research Projects and Cores to assist in data analysis, sensor platform testing and validation. In addition, the Administrative Core will assume responsibility for (a) planning and coordination of research activities within the U54 Center, (b) promote cross-disciplinary and cross- organizational interactions, (c) coordinate statistical analyses of experimental data, (d) ensure effective liaison with the NIEHS and Exposure Biology research projects, (d) ensure effective fiscal and resources management and planning, (e) preparing programmatic center documents and reports, and provide travel and conferencing arrangements, and (g) facilitate technology transfer planning.