CORE--GENOMICS /BIOINFORMATICS--ALZHEIMER'S DISEASE AND AUTISM

拟议研究的目标是通过预测新的候选基因和相互作用的基因产物的途径来告知和加强对常见遗传性疾病的遗传决定因素的研究，这些基因产物可能包含影响疾病易感性或预防疾病发展的遗传变异。这项研究将为候选基因和基因网络提供一个通道，这些候选基因和基因网络将分别在阿尔茨海默病（AD）和自闭症加谱系障碍（ASD）种类的大型家庭样本中进行基因分型。第二个目标是设计和应用适当的统计和计算方法来分析将从拟议的研究中出现的新型遗传数据集的类型，并确定疾病

The goal of the proposed studies is to inform and enhance the search for genetic determinants of common, heritable disease by predicting novel candidate genes, and pathways of interacting gene products, likely to harbor genetic variation that influences susceptibility to, or protection against, development of disease. This study will provide a conduit of candidate genes, and gene-networks, that will be genotyped in large, family-based sample collections of Alzheimer's Disease (AD) and autism plus spectrum disorder (ASD) kindreds, respectively. A second goal is to design and apply appropriate statistical and computational methods to analyze the type of novel genetic datasets that will emerge from the proposed studies, and to identify disease related genetic variants. This will require extensive use of evidence integration methods, biomedical literature datamining, and ontologies developed in Cores 9001 and 9002.