GENOMICS

基因组学

• 批准号: 7714262
• 负责人: Thomas Conrad GILLIAM
• 金额: $ 27.23万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-22 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714262
• 关键词: Area; Arts; Awareness; Bioinformatics; Biological Sciences; Clinical; Computer software; Confidentiality; Core Facility; DNA Sequence; DNA Sequencing Facility; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Detection; Ensure; Future; Genes; Genetic; Genome; Genomics; Genotype; Goals; Health Insurance Portability and Accountability Act; Housing; Individual; Laboratories; Peer Review; Phenotype; Research; Research Infrastructure; Research Personnel; Resources; Services; Solutions; Speed; Standards of Weights and Measures; Technology; University of Chicago Cancer Research Center; anticancer research; base; biomedical informatics; data acquisition; functional genomics; interdisciplinary collaboration; programs; quality assurance

The Genomics Core Facility (GCF) was created in 2006 by combining two existing institutional cores - the UCCRC-supported DNA Sequencing and Genotyping Facility and the Functional Genomics Facility - with the genomics-related bioinformatics services previously provided by the developing Biomedical Informatics Facility. These resources have become so integral to cutting-edge research in the biological sciences that essentially every laboratory-based investigator in the UCCRC will access them on a regular basis. While these facilities have previously operated independently, their functions overlap in complementary and necessary ways. The merger into a single, integrated Core, a task that will be completed with co-localization in dedicated space in the Knapp Center for Biomedical Discovery (KCBD; a new building which will be completed in 2008), will result in significant benefit to investigators. Over 82 peer-reviewed UCCRC investigators across all six Scientific Programs routinely use the combined Functional Genomics and DNA Sequencing and Genotyping Facilities, representing 44% of Facility usage. The Facility provides state-of-the-art microarray, DNA sequencing, and genotyping platforms with specialized databases for storing, managing, and manipulating both clinical information (phenotypes) and diverse types of genetic and genomic data (genotypes). Expert assistance in the detection technologies, as well as adapting the resulting data to modern database solutions using high-speed specialized hardware and sophisticated commercial and academic software tailored for genomics and bioinformatics research will provide UCCRC investigators who use the GCF the highest standards of data acquisition, protection, confidentiality, and HIPAA compliance currently available to academic researchers. The GCF is aimed towards biomedical researchers who are generally unfamiliar with whole genome and bioinformatics approaches, as well as experts seeking more sophisticated hardware, software, programming, or database solutions, or seeking to facilitate interdisciplinary collaborations. Major goals of the GCF are to provide investigators with scientific and technical staff who can assist with or collaborate on individual projects, provide an educational program that allows investigators to seek their own levels of expertise and sophistication in a given application, and raise awareness of new directions and major discoveries in the areas of genomics and bioinformatics.

基因组学核心基金(GCF)成立于2006年，结合了两个现有的机构核心- UCCRC支持的DNA测序和基因分型设施和功能基因组学设施- 与基因组学相关的生物信息学服务以前由正在开发的Biomedical 信息学设施。这些资源已经成为生物学领域尖端研究不可或缺的一部分 科学，基本上UCCRC的每个实验室调查员都会定期访问它们 基础。虽然这些设施以前都是独立运行的，但它们的功能在 相辅相成和必要的途径。合并成一个单一的、综合的核心，这项任务将是 在Knapp生物医学发现中心(KCBD； 一座将于2008年完工的新楼)，将为调查人员带来巨大的好处。超过82 在所有六个科学项目中，经过同行审查的UCCRC调查人员经常使用联合 功能基因组学、DNA测序和基因分型设施，占设施的44% 用法。 该设施提供最先进的微阵列、DNA测序和基因分型平台 用于存储、管理和操作临床信息(表型)和 不同类型的遗传和基因组数据(基因类型)。检测技术方面的专家协助， 以及使结果数据适应现代数据库解决方案 为基因组学和生物信息学量身定做的硬件和复杂的商业和学术软件 研究将为使用GCF的UCCRC调查人员提供最高标准的数据获取， 学术研究人员目前可获得的保护、保密和HIPAA合规性。 GCF针对的是通常不熟悉全基因组的生物医学研究人员 生物信息学方法，以及寻求更复杂的硬件、软件、 编程或数据库解决方案，或寻求促进跨学科合作。主要目标 向调查人员提供科学和技术人员，他们可以协助或 在个别项目上进行合作，提供一个教育计划，允许调查人员寻求他们的 在给定的应用程序中拥有自己的专业知识和复杂程度，并提高对新方向的认识 以及基因组学和生物信息学领域的重大发现。