Genetics of Common Heritable Disorders in Venezuela

委内瑞拉常见遗传性疾病的遗传学

• 批准号: 6935247
• 负责人: Thomas Conrad GILLIAM
• 金额: $ 38.54万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935247
• 关键词: South America; bioinformatics; clinical research; cooperative study; education evaluation /planning; ethics; family genetics; gene environment interaction; genetic disorder; genetic susceptibility; genome; health related legal; health science profession; health science research; human population genetics; linkage mapping; molecular genetics; neural degeneration; neurogenetics; postgraduate education; training

DESCRIPTION (provided by applicant): The goal of the proposed research-training program is to strengthen the capacity of Venezuelan scientists based at the University of Zulia to study genetics of common hereditable disorders relevant to Latin America and the Caribbean, and in particular to Venezuela. The strategy is to enhance the current research and training programs at the University of Zulia by: (1) training a critical mass of scientists and engineers in the design and conduct of modern genetic/genomic research (2) facilitating the development of a research and training infrastructure at the University of Zulia that will draw upon and focus clinical and scientific expertise throughout Western Venezuela (3) sustaining the research and training programs at the University of Zulia by establishing collaborative networks with Columbia University researchers studying the genetic basis of the most common complex hereditable disorders. The proposed training program seeks to capitalize upon current genetic and genomic research programs at Columbia University that overlap thematically with the focus on common heritable neurodegenerative disorders at the University of Zulia. The training program is designed to educate doctoral students and postdoctoral fellows in human genetics, including genetic epidemiology, population genetics, molecular genetics, clinical genetics, statistical genetics and bioinformatics, with a broad understanding on the ethical, legal and social issues related to human genetics research. The didactic component of the program includes a series of academic courses, seminars and laboratory rotations. In the research component each Fellow will work closely with a Preceptor on an independent research project of the Fellow's choosing and that is related to his/her future research in Venezuela. In addition Fellows will be exposed to the process of development of low-cost diagnostic methods that may facilitate the recognition of neurodegenerative disorders and the development of preventive or ameliorative treatment options. At the end of the program Fellows should understand the critical aspects of study design, methodology, and genetic and epidemiological theory relevant to the detection of complex disease loci and to specifically address the interaction of genetic factors with environmental and cultural factors. Emphasis will be given to defining tractable genetic targets and building productive collaborations.

描述(由申请人提供)：拟议的研究-培训计划的目标是加强委内瑞拉科学家在祖利亚大学研究与拉丁美洲和加勒比地区，特别是与委内瑞拉有关的常见遗传性疾病的遗传学的能力。该战略将通过以下方式加强祖利亚大学目前的研究和培训计划：(1)在现代遗传/基因组研究的设计和实施方面培训一大批科学家和工程师(2)促进祖利亚大学研究和培训基础设施的发展，该基础设施将利用和集中整个委内瑞拉西部的临床和科学专业知识(3)通过与哥伦比亚大学研究最常见复杂遗传性疾病的遗传基础的研究人员建立合作网络，维持祖利亚大学的研究和培训计划。拟议的培训计划寻求利用哥伦比亚大学目前的遗传和基因组研究项目，这些项目在主题上与祖利亚大学常见的可遗传神经退行性疾病的重点重叠。该培训计划旨在教育博士生和博士后研究员人类遗传学，包括遗传流行病学、群体遗传学、分子遗传学、临床遗传学、统计遗传学和生物信息学，并对与人类遗传学研究相关的伦理、法律和社会问题有广泛的理解。该计划的教学部分包括一系列学术课程、研讨会和实验室轮换。在研究部分，每名研究员将与一名P受体密切合作，开展一项由该研究员选择的独立研究项目，该项目与他/她今后在委内瑞拉的研究有关。此外，研究人员还将了解开发低成本诊断方法的过程，这些方法可能有助于确认神经退行性疾病，并制定预防或改善治疗方案。在项目结束时，研究员应了解研究设计、方法、遗传和流行病学理论中与复杂疾病位点检测相关的关键方面，并具体解决遗传因素与环境和文化因素之间的相互作用。重点将放在确定易于处理的遗传目标和建立富有成效的合作上。