Core F(B): Synthesis Design

脂质合成核心（核心F）将通过提供合成化学服务于LIPID MAPS联盟 支持Lipidomic核心组。核心F由两个子核心组成：脂质标准品，F（A）和 合成设计，F（B）。脂质标准品子核心由Avanti Polar Lipids，Inc.代表。这个子- 核心将作为LIPID MAPS财团的制造部门，因此有责任 （a）设计和执行由该联合体发现的新型脂质的合成路线，（B）产生新的 激动剂，例如Kdo 2-Lipid A，（c）产生可用作内标物的脂质产品，例如 稳定的同位素标记的化合物和含有奇数链脂肪酸的化合物，（d）产生脂质产物 可用作主要质谱标准品，如天然产物的合成类似物， (e)开发具有规定浓度和最长保质期的质谱标准品包装， (f)开发由核心F（B）开发的LDL氧化脂质模拟物的生产规模合成，和（g） 继续生产和稳定性测试在上一个资助期开发的产品。所有 所制造和表征的化合物将免费提供给联合体成员， 而更大的脂质社区将通过Avanti目录获得这些产品。 合成设计子核心将开发新型脂质化合物的合成途径，包括 活性剂存在于氧化LDL和奇数碳链脂肪酸中，具有不同程度的不饱和度。 核心F（B）将与脂质标准品子核心密切合作，以开发生产规模生产 这些化合物的生产工艺。 成功完成核心F的拟议具体目标将确保脂质组学核心 这些团体拥有纯净、稳定的化合物，这对完成《公约》的总体目标至关重要。 财团从本质上讲，Core F提供的血脂标准是研究的基础。 其他核心实验室的建议是基于。

The Lipid Synthesis Core (Core F) will serve the LIPID MAPS Consortium by providing synthetic chemistry support for the Lipidomic Core groups. Core F is composed of two sub-Cores: Lipid Standards, F(A) and Synthesis Design, F(B). The Lipid Standards sub-Core is represented by Avanti Polar Lipids, Inc. This sub- Core will serve as the manufacturing arm of the LIPID MAPS consortium, and as such has the responsibility to (a) design and execute synthetic routes to novel lipids discovered by the consortium, (b) produce novel agonists, such as Kdo2-Lipid A, (c) produce lipid products that can be used as internal standards, such as stable isotope-labeled compounds and compounds containing odd chain fatty acids, (d) produce lipid products that can be used as primary mass spectrometric standards, such as synthetic analogues of natural products, (e) develop packaging for mass spectrometric standards with defined concentrations and maximum shelf life, (f) develop production scale synthesis of the LDL oxidized lipid mimetic developed by Core F(B), and (g) continue the production and stability testing of products developed in the previous grant period. All of the compounds manufactured and characterized will be made available to the consortium members at no charge, while the larger lipid community will have access to these products through the Avanti catalog. The Synthesis Design sub-Core will develop synthetic pathways for novel lipid compounds including the active agent present in oxidized LDL and odd-carbon chain fatty acids with varying degrees of unsaturation. Core F(B) will work closely with the Lipid Standards sub-Core to develop production scale manufacturing processes for these compounds. The successful completion of the proposed specific aims of Core F will ensure that the Lipidomic Core groups have pure, stable compounds, which are essential to the completion of the overall objectives of the Consortium. In essence, the lipid standards provided by Core F are the foundations on which the research proposed by the other Core laboratories is based.