Metallo-beta-lactamases: predicting and combating antibiotic resistance

耐药细菌病原体的增加已成为一个主要的全球卫生问题。许多病原体使用一种特殊的酶，称为金属- β -内酰胺酶（MBL），来降解青霉素等抗生素。目前还没有临床上有用的这种酶的抑制剂。我们将使用复杂的技术来预测和对抗肺炎克雷伯菌的MBL耐药性，克雷伯菌是一种与医院获得性感染（如尿路感染）特别相关的病原体。

The increase of drug-resistant bacterial pathogens has become a major global health concern. Many pathogens employ a special enzyme, named metallo-beta-lactamase (MBL), to degrade antibiotics such as penicillin. No clinically useful inhibitors of this enzyme are available. We will use sophisticated techniques to predict and combat drug resistance of the MBL from Klebsiella pneumoniae, a pathogen associated in particular with hospital-acquired infections such as urinary tract infections.