BETA CELL FUNCTION USING THE HYPERGLYCEMIC CLAMP AFTER HEMIPANCREATECTOMY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本课题的目的是研究恒河猴胰岛β细胞对应激的适应机制。在非人类灵长类动物(NHP)中，β细胞对增加的分泌需求的适应机制尚未被研究。与人类不同，对胰岛形态和周转变化的测量可以在NHP中前瞻性地完成。虽然胰岛淀粉样蛋白沉积是NHP和人类T2 DM最典型的特征，但我们对淀粉样蛋白生物学和病理生理学的了解几乎完全与在啮齿动物上进行的研究有关。另一个研究淀粉样变性和B细胞衰竭的有价值的模型是培养和移植的人胰岛，它迅速发展为淀粉样变性、B细胞变性和功能障碍。目前还没有能够预防或减少胰岛淀粉样蛋白沉积的有效治疗方法取得成果。该项目旨在为填补其中一些空白作出贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to study the mechanisms of Beta-cell adaptation to stress in baboon n pancreatic islets. The mechanisms of Beta-cell adaptation to an increased secretory demand have not been studied in Non Human Primates (NHP). Unlike in humans, measurements of changes in islet morphology and turnover can be done prospectively in NHPs. Although islet amyloid deposition is the most typical feature of NHP and human T2DM, our knowledge on amyloid biology and pathophysiology is almost completely related on studies performed on rodents. Another valuable model for the study of amyloidosis and B-cell failure is provided by cultured and transplanted human islets, which rapidly develop amyloidosis, B-cell degeneration and dysfunction. No effective treatments capable to prevent or decrease islet amyloid deposition have yet come to fruition. This project is intended to contribute at filling some of these gaps.